褐色細胞腫の1治験例 : メトクロプラマイドとラベタロールの有用性について

Abstract

We report a case of pheochromocytoma in which the metoclorpramide test was performed, and labetalol administered, The patient was a 14-year-old female who was diagnosed to have ectopic pheochromocytoma by hormonal studies and radiological studies including CT analysis and aortography, Metoclorpramide, an antiemetic drug, was given to this patient as a stimulation test for the diagnosis of pheochromocytoma, originally described by Plouin in 1976, During the preoperative period, a significant increase in blood pressure was observed soon after venous injection of 10 mg metochlorpramide. The same test was performed shortly after the removal of the adenoma during operation and during the postoperative period, but it did not alter the blood pressure of the patient. During the operation, labetalol, a competive antagonist of both a- and p-adrenoceptors, was used to control the blood pressure. The operation was performed safely without any paroxysmal rise or fall of blood pressure. These results suggest that: 1) The metoclorpramide test is useful for the diagnosis of pheochromocytoma and for its recurrence after operation, and that 2) labetalol is an effective drug for controlling the blood pressure during pheochromocytoma operations, and is suitable for use as a substitute for phenoxybenzamin.