泌尿器科領域におけるBasic Fetoproteinの意義 - おもに睾丸腫瘍Markerとしての有用性 -

Abstract

The basic fetoprotein in the serum of patients with urogenital tract diseases was measured using radioimmunoassay, and the following results were obtained. Serum BFP values were divided into three groups: Negative, false positive and positive for values below 100ng/ml, 100-129ng/ml and above 130ng/ml, respectively. The BFP positive rate for the benign diseases was 21.2 % and particularly high in the cases of acute inflammation. The BFP positive rate for the patients with urogenital malignant tumors, was 46.3%. After radical therapy it was 9.5%. Serum BFP, β-HCG and AFP values were measured in the 31 cases of testicular tumor. The BFP positive rate was 55.0 % and the β-HCG positive rate was 40% for the 20 cases of seminoma. The BFP positive rate for 11 non-seminoma cases was 27.3%, theβ-HCG positive rate was 36.4% and the AFP (8 cases) positive rate was 62.5 %. If we regarded the case positive when at least one of the parameters, BFP, β-HCG or AFP was positive, 65.0% of the 20 cases of seminoma and 55.6% of the 11 non-seminoma cases were positive. It was concluded that the measurement of BFP is significantly efficient as a tumor marker for urogenital tumor; particularly for testicular tumors, the measurement of β-HCG, AFP and BFP in combination very useful.