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DCフィールド | 値 | 言語 |
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dc.contributor.author | Nakagawa, Masato | en |
dc.contributor.author | Takizawa, Nanako | en |
dc.contributor.author | Narita, Megumi | en |
dc.contributor.author | Ichisaka, Tomoko | en |
dc.contributor.author | Yamanaka, Shinya | en |
dc.contributor.alternative | 中川, 誠人 | ja |
dc.contributor.alternative | 山中, 伸弥 | ja |
dc.date.accessioned | 2010-07-28T00:27:09Z | - |
dc.date.available | 2010-07-28T00:27:09Z | - |
dc.date.issued | 2010-07-26 | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/2433/123272 | - |
dc.description | 形質転換活性を欠損したMycによるリプログラミング促進効果:L-Mycを用いた効率的なiPS細胞の樹立. 京都大学プレスリリース. 2010-07-27. | ja |
dc.description.abstract | Induced pluripotent stem cells (iPSCs) are generated from mouse and human fibroblasts by the introduction of three transcription factors: Oct3/4, Sox2, and Klf4. The proto-oncogene product c-Myc markedly promotes iPSC generation, but also increases tumor formation in iPSC-derived chimeric mice. We report that the promotion of iPSC generation by Myc is independent of its transformation property. We found that another Myc family member, L-Myc, as well as c-Myc mutants (W136E and dN2), all of which have little transformation activity, promoted human iPSC generation more efficiently and specifically compared with WT c-Myc. In mice, L-Myc promoted germline transmission, but not tumor formation, in the iPSC-derived chimeric mice. These data demonstrate that different functional moieties of the Myc proto-oncogene products are involved in the transformation and promotion of directed reprogramming. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The National Academy of Sciences | en |
dc.rights | © 2010 the National Academy of Sciences | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | induced pluripotent stem cell | en |
dc.subject | embryonic stem cell | en |
dc.subject | regenerative medicine | en |
dc.subject | proto-oncogene | en |
dc.title | Promotion of direct reprogramming by transformation-deficient Myc | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10808769 | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences | en |
dc.identifier.volume | 107 | - |
dc.identifier.issue | 32 | - |
dc.identifier.spage | 14152 | - |
dc.identifier.epage | 14157 | - |
dc.relation.doi | 10.1073/pnas.1009374107 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20660764 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2010/100727_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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