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DCフィールド | 値 | 言語 |
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dc.contributor.author | Miyata, Jun | en |
dc.contributor.author | Yamada, Makiko | en |
dc.contributor.author | Namiki, Chihiro | en |
dc.contributor.author | Hirao, Kazuyuki | en |
dc.contributor.author | Saze, Teruyasu | en |
dc.contributor.author | Fujiwara, Hironobu | en |
dc.contributor.author | Shimizu, Mitsuaki | en |
dc.contributor.author | Kawada, Ryosaku | en |
dc.contributor.author | Fukuyama, Hidenao | en |
dc.contributor.author | Sawamoto, Nobukatsu | en |
dc.contributor.author | Hayashi, Takuji | en |
dc.contributor.author | Murai, Toshiya | en |
dc.contributor.alternative | 宮田, 淳 | ja |
dc.date.accessioned | 2010-09-01T04:39:14Z | - |
dc.date.available | 2010-09-01T04:39:14Z | - |
dc.date.issued | 2010-06 | - |
dc.identifier.issn | 0920-9964 | - |
dc.identifier.uri | http://hdl.handle.net/2433/123551 | - |
dc.description.abstract | BACKGROUND: The pathology of schizophrenia is thought to involve multiple gray and white matter regions. A number of studies have revealed impaired social cognition in schizophrenia. Some evidence suggests an association of this social cognition deficit with gray matter reductions in 'social brain' areas. However, no study has yet revealed the association between social cognition abilities and white matter abnormalities in schizophrenia patients. METHODS: Twenty-six schizophrenia patients and 27 healthy controls underwent the Perception of Affect Task (PAT), which consisted of four subtasks measuring different aspects of emotion attribution. Voxelwise group comparison of white matter fractional anisotropy (FA) was performed using tract-based spatial statistics (TBSS). The relation between impaired social cognition ability and FA reduction was examined in patients for each subtask, using simple regression analysis within brain areas that showed a significant FA reduction in patients compared with controls. The same correlational analysis was also performed for healthy controls in the whole brain. RESULTS: Schizophrenia patients showed reduced emotion attribution ability compared with controls in all four subtasks. The facial emotion perception subtask showed a significant correlation with FA reductions in the left occipital white matter region and left posterior callosal region. The correlational analyses in healthy controls revealed no significant correlation of FA with any of the PAT subtasks. CONCLUSIONS: Our voxelwise correlational analysis of white matter provided a potential neural basis for the social cognition impairments in schizophrenia, in support of the disconnection hypothesis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier | en |
dc.rights | © 2010 Elsevier B.V. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Corpus callosum | en |
dc.subject | Diffusion tensor imaging | en |
dc.subject | Disconnection hypothesis | en |
dc.subject | Facial emotion perception | en |
dc.subject | Inferior longitudinal fasciculus | en |
dc.subject | Tract-based spatial statistics | en |
dc.subject.mesh | Adult | en |
dc.subject.mesh | Brain/pathology | en |
dc.subject.mesh | Brain Mapping | en |
dc.subject.mesh | Cognition Disorders/diagnosis | en |
dc.subject.mesh | Cognition Disorders/pathology | en |
dc.subject.mesh | Corpus Callosum/pathology | en |
dc.subject.mesh | Dominance, Cerebral/physiology | en |
dc.subject.mesh | Emotions | en |
dc.subject.mesh | Facial Expression | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Image Enhancement | en |
dc.subject.mesh | Image Processing, Computer-Assisted | en |
dc.subject.mesh | Magnetic Resonance Imaging | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Nerve Fibers, Myelinated/pathology | en |
dc.subject.mesh | Neuropsychological Tests | en |
dc.subject.mesh | Occipital Lobe/pathology | en |
dc.subject.mesh | Pattern Recognition, Visual | en |
dc.subject.mesh | Personal Construct Theory | en |
dc.subject.mesh | Reference Values | en |
dc.subject.mesh | Schizophrenia/diagnosis | en |
dc.subject.mesh | Schizophrenia/pathology | en |
dc.subject.mesh | Schizophrenic Psychology | en |
dc.subject.mesh | Social Perception | en |
dc.title | Reduced white matter integrity as a neural correlate of social cognition deficits in schizophrenia. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10703465 | - |
dc.identifier.jtitle | Schizophrenia research | en |
dc.identifier.volume | 119 | - |
dc.identifier.issue | 1-3 | - |
dc.identifier.spage | 232 | - |
dc.identifier.epage | 239 | - |
dc.relation.doi | 10.1016/j.schres.2009.12.038 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20097045 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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