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dc.contributor.author | 市丸, 直嗣 | ja |
dc.contributor.author | 矢澤, 浩治 | ja |
dc.contributor.author | 高原, 史郎 | ja |
dc.contributor.alternative | Ichimaru, Naotsugu | en |
dc.contributor.alternative | Yazawa, Koji | en |
dc.contributor.alternative | Takahara, Shiro | en |
dc.date.accessioned | 2010-09-01T09:16:06Z | - |
dc.date.available | 2010-09-01T09:16:06Z | - |
dc.date.issued | 2010-08 | - |
dc.identifier.issn | 0018-1994 | - |
dc.identifier.uri | http://hdl.handle.net/2433/123557 | - |
dc.description.abstract | The research performed at the Department of Urology Osaka University Graduate School of Medicine is overviewed. Renal ischemia-reperfusion (I/R) injury is inevitable in transplantation and is related to longterm graft function. MF-1, a bifunctional hepatocyte growth factor-macrophage stimulating protein chimera, was found to prevent apoptosis. In our study, MF-1 directly guarded cultured proximal tubular epithelial cells from hypoxia-induced necrosis and apoptosis in vitro, and MF-1 treatment ameliorated renal dysfunction by preventing apoptosis in rat I/R injury model. The erythropoietin molecule modified by carbamylation (CEPO) has been identified and was demonstrated to protect several organs without increasing the hemoglobin concentration. The therapeutic effect of CEPO was evaluated using an endothelial tube formation assay, and a rat ischemia-reperfusion injury model. CEPO treatment induced more capillarylike formation than EPO. CEPO-treated kidneys showed minimal tubular apoptosis with increased peritubular capillary endothelial cells. We identified a new therapeutic approach using CEPO to protect the kidney from ischemia-reperfusion injury by promoting angiogenesis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | jpn | - |
dc.publisher | 泌尿器科紀要刊行会 | ja |
dc.rights | 許諾条件により本文は2011-09-01に公開 | ja |
dc.subject | Kidney transplantation | en |
dc.subject | Hepatocyte growth factor | en |
dc.subject | Carbamylated erythropoietin | en |
dc.subject.ndc | 494.9 | - |
dc.title | 腎移植: Marginal 症例への対応 - 基礎研究からの今後の展望 (第58回日本泌尿器科学会中部総会(金沢)) | ja |
dc.title.alternative | Kidney Transplantation: How Shall We Deal with Marginal Cases ? - Future Prospects from Basic Research | en |
dc.type | departmental bulletin paper | - |
dc.type.niitype | Departmental Bulletin Paper | - |
dc.identifier.ncid | AN00208315 | - |
dc.identifier.jtitle | 泌尿器科紀要 | ja |
dc.identifier.volume | 56 | - |
dc.identifier.issue | 8 | - |
dc.identifier.spage | 481 | - |
dc.identifier.epage | 484 | - |
dc.textversion | publisher | - |
dc.sortkey | 12 | - |
dc.address | 大阪大学大学院医学系研究科器官制御外科学講座(泌尿器科),大阪中央病院泌尿器科 | ja |
dc.address | 大阪大学大学院医学系研究科器官制御外科学講座(泌尿器科) | ja |
dc.address | 大阪大学大学院医学系研究科先端移植基盤医療学講座 | ja |
dc.startdate.bitstreamsavailable | 2011-09-01 | - |
dc.address.alternative | The Department of Specific Organ Regulation (Urology), Osaka University Graduate School of Medicine and The Department of Urology, Osaka Central Hospital | en |
dc.address.alternative | The Department of Specific Organ Regulation (Urology), Osaka University Graduate School of Medicine | en |
dc.address.alternative | The Department of Advanced Technology for Transplantation, Osaka University Graduate School of Medicine | en |
dc.identifier.pmid | 20808071 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0018-1994 | - |
dc.identifier.jtitle-alternative | Acta urologica Japonica | la |
dc.identifier.jtitle-alternative | Hinyokika Kiyo | en |
出現コレクション: | Vol.56 No.8 |
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