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タイトル: | Gastrointestinal follicular lymphoma: review of the literature. |
著者: | Yamamoto, Shuji Nakase, Hiroshi Yamashita, Kouhei Matsuura, Minoru Takada, Mariko Kawanami, Chiharu Chiba, Tsutomu |
著者名の別形: | 山本, 修司 仲瀬, 裕司 |
キーワード: | Follicular lymphoma Gastrointestinal tract Multiple lymphomatous polyposis |
発行日: | Apr-2010 |
出版者: | Springer |
誌名: | Journal of gastroenterology |
巻: | 45 |
号: | 4 |
開始ページ: | 370 |
終了ページ: | 388 |
抄録: | Gastrointestinal follicular lymphoma (GI-FL) is a relatively rare disease, accounting for only 1%-3.6% of gastrointestinal non-Hodgkin's lymphoma. Although the duodenum and terminal ileum are considered to be the most common sites of origin, the development of wireless capsule endoscopy and double-balloon enteroscopy has increased the detection of GI-FL in every part of the small intestine. Approximately 70% of patients with GI-FL are estimated to have multiple lesions throughout the entire gastrointestinal tract. FL is a low-grade lymphoma that usually develops very slowly. If the lymphoma causes no symptoms, immediate treatment may not be necessary. Standard therapy has not yet been established for GI-FL, but chemotherapy, radiotherapy, monoclonal antibody therapy, or a combination of these therapies, is sometimes performed based on the therapeutic regimens for nodal FL. Regimens including conventional chemotherapy with rituximab, which achieve high response rates in nodal FL, are commonly used for GI-FL. The long-term clinical outcome of GI-FL is unclear. The results of a few series on the long-term outcomes of patients with GI-FL treated with conventional therapy indicate a median relapse-free time ranging from 31 to 45 months. On the other hand, in patients with GI-FL who were followed without treatment, the median time to disease progression was 37.5 months. Thus, whether to initiate aggressive therapy or whether to continue watchful waiting in patients with GI-FL is a critically important decision. Ongoing research on biomarkers to guide individualized GI-FL therapy may provide invaluable information that will lead to the establishment of a standard therapeutic regimen. |
著作権等: | The original publication is available at www.springerlink.com This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/126697 |
DOI(出版社版): | 10.1007/s00535-009-0182-z |
PubMed ID: | 20084529 |
出現コレクション: | 学術雑誌掲載論文等 |
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