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j.neulet.2010.07.055.pdf | 396.89 kB | Adobe PDF | 見る/開く |
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dc.contributor.author | Maesako, Masato | en |
dc.contributor.author | Uemura, Kengo | en |
dc.contributor.author | Kubota, Masakazu | en |
dc.contributor.author | Ando, Koichi | en |
dc.contributor.author | Kuzuya, Akira | en |
dc.contributor.author | Asada, Megumi | en |
dc.contributor.author | Kihara, Takeshi | en |
dc.contributor.author | Kinoshita, Ayae | en |
dc.contributor.alternative | 木下, 彩栄 | ja |
dc.date.accessioned | 2010-10-08T06:29:58Z | - |
dc.date.available | 2010-10-08T06:29:58Z | - |
dc.date.issued | 2010-10-15 | - |
dc.identifier.issn | 0304-3940 | - |
dc.identifier.uri | http://hdl.handle.net/2433/126716 | - |
dc.description.abstract | Recently, insulin signaling has been highlighted in the pathology of Alzheimer's disease (AD). Although the association between insulin signaling and Tau pathology has been investigated in several studies, the interaction between insulin signaling and Presenilin 1 (PS1), a key molecule of amyloid beta (Abeta) pathology, has not been elucidated so far. In this study, we demonstrated that insulin inhibited PS1 phosphorylation at serine residues (serine 353, 357) via phosphatidylinositol 3-kinase (PI3K)/Akt signal pathway and strengthened the trimeric complex of PS1/N-cadherin/beta-catenin, consequently relocalizing PS1 to the cell surface. Since our recent report suggests that PS1/N-cadherin/beta-catenin complex regulates Abeta production, it is likely that insulin signaling affects Abeta pathology by regulating PS1 localization. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ireland Ltd | en |
dc.rights | © 2010 Elsevier Ireland Ltd | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Alzheimer's disease | en |
dc.subject | Insulin | en |
dc.subject | Preseninlin 1 | en |
dc.subject | Phosphorylation | en |
dc.title | Insulin regulates Presenilin 1 localization via PI3K/Akt signaling. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00754925 | - |
dc.identifier.jtitle | Neuroscience letters | en |
dc.identifier.volume | 483 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 157 | - |
dc.identifier.epage | 161 | - |
dc.relation.doi | 10.1016/j.neulet.2010.07.055 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20696212 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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