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タイトル: | Protective effect of aripiprazole against glutamate cytotoxicity in dopaminergic neurons of rat mesencephalic cultures. |
著者: | Matsuo, Takaaki Izumi, Yasuhiko Kume, Toshiaki Takada-Takatori, Yuki Sawada, Hideyuki Akaike, Akinori |
著者名の別形: | 松尾, 剛明 赤池, 昭紀 |
キーワード: | Aripiprazole Dopamine Glutamate cytotoxicity Intracellular dopamine content Neuroprotective effec |
発行日: | 6-Sep-2010 |
出版者: | Elsevier Ireland Ltd |
誌名: | Neuroscience letters |
巻: | 481 |
号: | 2 |
開始ページ: | 78 |
終了ページ: | 81 |
抄録: | Aripiprazole, a dopamine D(2) receptor partial agonist, is used to treat schizophrenia. Although aripiprazole has been reported to protect non-dopaminergic neurons, its effect on dopaminergic neurons has yet to be investigated. In the present study, we examined whether aripiprazole protected dopaminergic neurons against glutamate-induced cytotoxicity in rat mesencephalic cultures. Pretreatment with aripiprazole protected dopaminergic neurons in a concentration-dependent manner. The neuroprotective effect was not attenuated by sulpiride, a dopamine D(2) receptor antagonist, suggesting that the effect is independent of dopamine D(2) receptors. Aripiprazole reduced intracellular dopamine content in a concentration-dependent manner. In addition, its neuroprotective effect was partially inhibited when dopamine was added. These results suggest that aripiprazole protects dopaminergic neurons against glutamate cytotoxicity partly by reducing intracellular dopamine content. |
著作権等: | © 2010 Elsevier Ireland Ltd この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/126831 |
DOI(出版社版): | 10.1016/j.neulet.2010.06.049 |
PubMed ID: | 20600606 |
出現コレクション: | 学術雑誌掲載論文等 |
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