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DCフィールド | 値 | 言語 |
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dc.contributor.author | Chandana, Ediriweera P S | en |
dc.contributor.author | Maeda, Yasuhiro | en |
dc.contributor.author | Ueda, Akihiko | en |
dc.contributor.author | Kiyonari, Hiroshi | en |
dc.contributor.author | Oshima, Naoko | en |
dc.contributor.author | Yamamoto, Mako | en |
dc.contributor.author | Kondo, Shunya | en |
dc.contributor.author | Oh, Junseo | en |
dc.contributor.author | Takahashi, Rei | en |
dc.contributor.author | Yoshida, Yoko | en |
dc.contributor.author | Kawashima, Satoshi | en |
dc.contributor.author | Alexander, David B | en |
dc.contributor.author | Kitayama, Hitoshi | en |
dc.contributor.author | Takahashi, Chiaki | en |
dc.contributor.author | Tabata, Yasuhiko | en |
dc.contributor.author | Matsuzaki, Tomoko | en |
dc.contributor.author | Noda, Makoto | en |
dc.contributor.alternative | 野田, 亮 | ja |
dc.date.accessioned | 2010-10-18T04:42:18Z | - |
dc.date.available | 2010-10-18T04:42:18Z | - |
dc.date.issued | 2010-08-06 | - |
dc.identifier.issn | 1471-213X | - |
dc.identifier.uri | http://hdl.handle.net/2433/128759 | - |
dc.description.abstract | BACKGROUND: Developmental angiogenesis proceeds through multiple morphogenetic events including sprouting, intussusception, and pruning. Mice lacking the membrane-anchored metalloproteinase regulator Reck die in utero around embryonic day 10.5 with halted vascular development; however, the mechanisms by which this phenotype arises remain unclear. RESULTS: We found that Reck is abundantly expressed in the cells associated with blood vessels undergoing angiogenesis or remodelling in the uteri of pregnant female mice. Some of the Reck-positive vessels show morphological features consistent with non-sprouting angiogenesis. Treatment with a vector expressing a small hairpin RNA against Reck severely disrupts the formation of blood vessels with a compact, round lumen. Similar defects were found in the vasculature of Reck-deficient or Reck conditional knockout embryos. CONCLUSIONS: Our findings implicate Reck in vascular remodeling, possibly through non-sprouting angiogenesis, in both maternal and embyonic tissues. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | BioMed Central Ltd. | en |
dc.rights | © 2010 Chandana et al; licensee BioMed Central Ltd. | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Blood Vessels/metabolism | en |
dc.subject.mesh | Embryo Implantation | en |
dc.subject.mesh | Embryo, Mammalian/blood supply | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Membrane Glycoproteins/metabolism | en |
dc.subject.mesh | Mice | en |
dc.subject.mesh | Neovascularization, Physiologic | en |
dc.subject.mesh | Pregnancy | en |
dc.subject.mesh | Uterus/blood supply | en |
dc.title | Involvement of the Reck tumor suppressor protein in maternal and embryonic vascular remodeling in mice. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA12034832 | - |
dc.identifier.jtitle | BMC developmental biology | en |
dc.identifier.volume | 10 | - |
dc.relation.doi | 10.1186/1471-213X-10-84 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 84 | - |
dc.identifier.pmid | 20691046 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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