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j.coi.2010.06.001.pdf | 73.89 kB | Adobe PDF | 見る/開く |
タイトル: | Helicobacter pylori-induced activation-induced cytidine deaminase expression and carcinogenesis. |
著者: | Marusawa, Hiroyuki Chiba, Tsutomu |
著者名の別形: | 丸澤, 宏之 |
発行日: | Aug-2010 |
出版者: | Elsevier Ltd |
誌名: | Current opinion in immunology |
巻: | 22 |
号: | 4 |
開始ページ: | 442 |
終了ページ: | 447 |
抄録: | Tumorigenesis is a multistep process in which the accumulation of genetic alterations drives the transformation of normal cells into malignant derivatives. Activation-induced cytidine deaminase (AID) contributes to immune system diversity by inducing somatic hypermutations and class-switch recombinations of human immunoglobulin genes. The mutagenic activity of AID, however, can also induce genetic changes in various genes and may lead to the development of cancer. Helicobacter pylori, a class 1 carcinogen for human gastric cancer, affects AID expression by two different mechanisms, introduction of bacterial virulence factors into host cells and induction of inflammatory responses, thereby contributing to the accumulation of mutations in tumor-related genes. Aberrant AID activity may therefore be a novel link between infection and carcinogenesis. |
著作権等: | © 2010 Elsevier Ltd この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/128867 |
DOI(出版社版): | 10.1016/j.coi.2010.06.001 |
PubMed ID: | 20667704 |
出現コレクション: | 学術雑誌掲載論文等 |
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