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dc.contributor.author | Yanagita, Ryo C | en |
dc.contributor.author | Kamachi, Hiroaki | en |
dc.contributor.author | Tanaka, Keisuke | en |
dc.contributor.author | Murakami, Akira | en |
dc.contributor.author | Nakagawa, Yu | en |
dc.contributor.author | Tokuda, Harukuni | en |
dc.contributor.author | Nagai, Hiroshi | en |
dc.contributor.author | Irie, Kazuhiro | en |
dc.contributor.alternative | 入江, 一浩 | ja |
dc.date.accessioned | 2010-11-04T01:46:30Z | - |
dc.date.available | 2010-11-04T01:46:30Z | - |
dc.date.issued | 2010-10-15 | - |
dc.identifier.issn | 0960-894X | - |
dc.identifier.uri | http://hdl.handle.net/2433/130698 | - |
dc.description.abstract | The 18-deoxy derivative (3) of a simplified analogue (1) of aplysiatoxin with antiproliferative activity was synthesized to examine the role of the phenolic hydroxyl group at position 18 in the biological activities of 1. Compound 3 as well as 1 showed significant affinity for protein kinase Cδ (PKCδ), and the antiproliferative activity of 3 was slightly higher than that of 1. However, the anti-tumor-promoting activity of 3 was less than that of 1 in vitro, suggesting that the phenolic hydroxyl group of 1 is necessary for the anti-tumor-promoting activity but not for the binding of PKCδ and antiproliferative activity. Moreover, PKC isozyme selectivity of 3 was similar to that of 1, suggesting non-PKC receptors for these compounds to play some roles in the anti-tumor-promoting activity of 1. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Ltd | en |
dc.rights | © 2010 Elsevier Ltd | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Protein kinase C | en |
dc.subject | Tumor promoter | en |
dc.subject | Bryostatin | en |
dc.subject | Antiproliferative | en |
dc.subject | Epstein-Barr virus | en |
dc.subject | Aplysiatoxin | en |
dc.subject | Phorbol ester | en |
dc.title | Role of the phenolic hydroxyl group in the biological activities of simplified analogue of aplysiatoxin with antiproliferative activity. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA1079577X | - |
dc.identifier.jtitle | Bioorganic & medicinal chemistry letters | en |
dc.identifier.volume | 20 | - |
dc.identifier.issue | 20 | - |
dc.identifier.spage | 6064 | - |
dc.identifier.epage | 6066 | - |
dc.relation.doi | 10.1016/j.bmcl.2010.08.051 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20817520 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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