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DCフィールド | 値 | 言語 |
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dc.contributor.author | Tsujikawa, Akitaka | en |
dc.contributor.author | Ooto, Sotaro | en |
dc.contributor.author | Yamashiro, Kenji | en |
dc.contributor.author | Tamura, Hiroshi | en |
dc.contributor.author | Otani, Atsushi | en |
dc.contributor.author | Yoshimura, Nagahisa | en |
dc.contributor.alternative | 辻川, 明孝 | ja |
dc.date.accessioned | 2010-11-08T00:30:56Z | - |
dc.date.available | 2010-11-08T00:30:56Z | - |
dc.date.issued | 2010-07 | - |
dc.identifier.issn | 0021-5155 | - |
dc.identifier.uri | http://hdl.handle.net/2433/130712 | - |
dc.description.abstract | PURPOSE: To evaluate the efficacy of intravitreal bevacizumab (IVB) in eyes with polypoidal choroidal vasculopathy (PCV). METHODS: Seventeen eyes of 16 patients with either subfoveal or juxtafoveal PCV were treated with IVB. As the initial treatment, ten eyes were treated with a single injection of bevacizumab and seven were treated with three monthly injections. Additional IVB injections were performed in 15 eyes when either a recurrent or residual exudative change was seen. Follow-up after initiation of IVB ranged from 12 to 30 months (mean, 20.7 +/- 5.7 months). RESULTS: The mean foveal thickness before IVB (492 +/- 205 microm) decreased to 384 +/- 181 microm at 3 months (P = 0.0008), and with additional IVB for recurrent exudative changes, the foveal thickness remained significantly reduced at 12 months (392 +/- 203 microm, P = 0.0270). Mean visual acuity at baseline (0.54 +/- 0.38 in logMAR) somewhat improved to 0.45 +/- 0.32 at 3 months (P = 0.156). However, the improvement in visual acuity then subsided, and returned to the pretreatment value at 12 months (0.54 +/- 0.39). CONCLUSIONS: In eyes with PCV, IVB can reduce the exudative change and can maintain visual function for at least 1 year. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Springer | en |
dc.rights | The original publication is available at www.springerlink.com | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | age-related macular degeneration | en |
dc.subject | bevacizumab | en |
dc.subject | polypoidal choroidal vasculopathy | en |
dc.subject.mesh | Aged | en |
dc.subject.mesh | Aged, 80 and over | en |
dc.subject.mesh | Angiogenesis Inhibitors/administration & dosage | en |
dc.subject.mesh | Antibodies, Monoclonal/administration & dosage | en |
dc.subject.mesh | Choroid/blood supply | en |
dc.subject.mesh | Choroid Diseases/diagnosis | en |
dc.subject.mesh | Choroid Diseases/drug therapy | en |
dc.subject.mesh | Choroid Diseases/physiopathology | en |
dc.subject.mesh | Female | en |
dc.subject.mesh | Fluorescein Angiography | en |
dc.subject.mesh | Follow-Up Studies | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Injections | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Middle Aged | en |
dc.subject.mesh | Peripheral Vascular Diseases/diagnosis | en |
dc.subject.mesh | Peripheral Vascular Diseases/drug therapy | en |
dc.subject.mesh | Peripheral Vascular Diseases/physiopathology | en |
dc.subject.mesh | Retreatment | en |
dc.subject.mesh | Tomography, Optical Coherence | en |
dc.subject.mesh | Treatment Outcome | en |
dc.subject.mesh | Vascular Endothelial Growth Factor A/antagonists & inhibitors | en |
dc.subject.mesh | Visual Acuity/physiology | en |
dc.subject.mesh | Vitreous Body | en |
dc.title | Treatment of polypoidal choroidal vasculopathy by intravitreal injection of bevacizumab. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00691177 | - |
dc.identifier.jtitle | Japanese journal of ophthalmology | en |
dc.identifier.volume | 54 | - |
dc.identifier.issue | 4 | - |
dc.identifier.spage | 310 | - |
dc.identifier.epage | 319 | - |
dc.relation.doi | 10.1007/s10384-010-0813-1 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20700799 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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