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タイトル: DNA-based nano-sized systems for pharmaceutical and biomedical applications.
著者: Nishikawa, Makiya  kyouindb  KAKEN_id
Rattanakiat, Sakulrat
Takakura, Yoshinobu  kyouindb  KAKEN_id
著者名の別形: 西川, 元也
キーワード: DNA
Nano-assembly
Drug delivery
Innate immunity
Toll-like receptor
CpG motif
発行日: 30-Apr-2010
出版者: Elsevier B.V.
誌名: Advanced drug delivery reviews
巻: 62
号: 6
開始ページ: 626
終了ページ: 632
抄録: DNA is one of the most important components for all living organisms and many species, including humans, use DNA to store and transmit genetic information to new generations. Recent advances in the handling of DNA have made it possible to use DNA as a building block of nano-sized materials with precisely designed architectures. Although various approaches have been proposed to obtain DNA assemblies with designed architecture in the nano- to micrometer range, there is little information about their interaction with biological components, including target molecules. Understanding the interaction between DNA assemblies and the body is highly important for successful pharmaceutical and biomedical applications. Here, we first review the basic aspects of externally administered DNA molecules, including the stability, permeability and delivery issues. Then, we discuss the unique responses observed in the interaction of structured DNA assemblies and cells expressing Toll-like receptor-9, the receptor responsible for the recognition of unmethylated CpG dinucleotides that are abundant in the DNA of invading pathogens, such as bacteria and viruses.
著作権等: © 2010 Elsevier B.V.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/131742
DOI(出版社版): 10.1016/j.addr.2010.03.006
PubMed ID: 20230867
出現コレクション:学術雑誌掲載論文等

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