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タイトル: | Age-related cortical thinning in schizophrenia. |
著者: | Kubota, Manabu Miyata, Jun https://orcid.org/0000-0003-1803-1975 (unconfirmed) Yoshida, Hidefumi Hirao, Kazuyuki Fujiwara, Hironobu Kawada, Ryosaku Fujimoto, Shinsuke Tanaka, Yusuke Sasamoto, Akihiko Sawamoto, Nobukatsu Fukuyama, Hidenao Murai, Toshiya |
著者名の別形: | 久保田, 学 |
キーワード: | MRI Cortical thickness Surface-based analysis FreeSurfer Aging Progression |
発行日: | Jan-2011 |
出版者: | Elsevier B.V. |
誌名: | Schizophrenia research |
巻: | 125 |
号: | 1 |
開始ページ: | 21 |
終了ページ: | 29 |
抄録: | Although the effects of aging on the neural correlates of schizophrenia have been researched for many years, no clear conclusion has been reached. While some studies have demonstrated progressive age-related gray matter reductions in schizophrenia, other studies have not found evidence of progression. Moreover, it remains unclear whether the influence of aging on global or regional cortical thickness differs between schizophrenia patients and healthy controls. This study aimed to confirm previous reports of reduced cortical thickness in schizophrenia, and to investigate the effects of age on global and regional cortical thickness. Eighty-three patients with schizophrenia (six first-episode patients and 77 chronic patients; age range=18-55 years) and 90 age-, gender- and education-matched healthy controls (age range=19-56 years) underwent structural magnetic resonance imaging (MRI) using a 3-Tesla scanner. Surface-based analysis was applied to assess cortical thickness in the whole brain. The patient group exhibited both global and regional cortical thinning in regions including the prefrontal and temporal cortices. The correlation between age and cortical thickness showed a similar pattern in patients and controls, both globally and regionally. These results suggest that the reduction of cortical thickness in schizophrenia might not be progressive over the course of the illness, indicating that pathological processes occur in a relatively limited period of time around the onset of illness. |
著作権等: | © 2010 Elsevier B.V. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/134575 |
DOI(出版社版): | 10.1016/j.schres.2010.10.004 |
PubMed ID: | 21036016 |
出現コレクション: | 学術雑誌掲載論文等 |
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