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j.micinf.2010.10.001.pdf | 1.35 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Saito, Akatsuki | en |
dc.contributor.author | Nomaguchi, Masako | en |
dc.contributor.author | Iijima, Sayuki | en |
dc.contributor.author | Kuroishi, Ayumu | en |
dc.contributor.author | Yoshida, Tomoyuki | en |
dc.contributor.author | Lee, Young-Jung | en |
dc.contributor.author | Hayakawa, Toshiyuki | en |
dc.contributor.author | Kono, Ken | en |
dc.contributor.author | Nakayama, Emi E | en |
dc.contributor.author | Shioda, Tatsuo | en |
dc.contributor.author | Yasutomi, Yasuhiro | en |
dc.contributor.author | Adachi, Akio | en |
dc.contributor.author | Matano, Tetsuro | en |
dc.contributor.author | Akari, Hirofumi | en |
dc.contributor.alternative | 明里, 宏文 | ja |
dc.date.accessioned | 2011-01-19T07:03:05Z | - |
dc.date.available | 2011-01-19T07:03:05Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 1286-4579 | - |
dc.identifier.uri | http://hdl.handle.net/2433/134587 | - |
dc.description.abstract | Human immunodeficiency virus type 1 (HIV-1) hardly replicates in Old World monkeys. Recently, a mutant HIV-1 clone, NL-DT5R, in which a small part of gag and the entire vif gene are replaced with SIVmac239-derived ones, was shown to be able to replicate in pigtail monkeys but not in rhesus monkeys (RM). In the present study, we found that a modified monkey-tropic HIV-1 (HIV-1mt), MN4-5S, acquired the ability to replicate efficiently in cynomolgus monkeys as compared with the NL-DT5R, while neither NL-DT5R nor MN4-5S replicated in RM cells. These results suggest that multiple determinants may be involved in the restriction of HIV-1 replication in macaques, depending on the species of macaques. The new HIV-1mt clone will be useful for studying molecular mechanisms by which anti-viral host factors regulate HIV-1 replication in macaques. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Masson SAS | en |
dc.rights | © 2010 Institut Pasteur Published by Elsevier Masson SAS | en |
dc.rights | この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version. | ja |
dc.subject | HIV-1 | en |
dc.subject | Old World monkey | en |
dc.subject | TRIM5α | en |
dc.title | Improved capacity of a monkey-tropic HIV-1 derivative to replicate in cynomolgus monkeys with minimal modifications. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11314560 | - |
dc.identifier.jtitle | Microbes and infection / Institut Pasteur | en |
dc.identifier.volume | 13 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 58 | - |
dc.identifier.epage | 64 | - |
dc.relation.doi | 10.1016/j.micinf.2010.10.001 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20955815 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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