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タイトル: Heptad repeat-derived peptides block protease-mediated direct entry from the cell surface of severe acute respiratory syndrome coronavirus but not entry via the endosomal pathway.
著者: Ujike, Makoto
Nishikawa, Hiroki
Otaka, Akira
Yamamoto, Naoki
Yamamoto, Norio
Matsuoka, Masao  KAKEN_id
Kodama, Eiichi
Fujii, Nobutaka  KAKEN_id
Taguchi, Fumihiro
著者名の別形: 藤井, 信孝
発行日: Jan-2008
出版者: American Society for Microbiology
誌名: Journal of virology
巻: 82
号: 1
開始ページ: 588
終了ページ: 592
抄録: The peptides derived from the heptad repeat (HRP) of severe acute respiratory syndrome coronavirus (SCoV) spike protein (sHRPs) are known to inhibit SCoV infection, yet their efficacies are fairly low. Recently our research showed that some proteases facilitated SCoV's direct entry from the cell surface, resulting in a more efficient infection than the previously known infection via endosomal entry. To compare the inhibitory effect of the sHRP in each pathway, we selected two sHRPs, which showed a strong inhibitory effect on the interaction of two heptad repeats in a rapid and virus-free in vitro assay system. We found that they efficiently inhibited SCoV infection of the protease-mediated cell surface pathway but had little effect on the endosomal pathway. This finding suggests that sHRPs may effectively prevent infection in the lungs, where SCoV infection could be enhanced by proteases produced in this organ. This is the first observation that HRP exhibits different effects on virus that takes the endosomal pathway and virus that enters directly from the cell surface.
著作権等: © 2011 by the American Society for Microbiology.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/137208
DOI(出版社版): 10.1128/JVI.01697-07
PubMed ID: 17942557
出現コレクション:学術雑誌掲載論文等

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