このアイテムのアクセス数: 428
このアイテムのファイル:
| ファイル | 記述 | サイズ | フォーマット | |
|---|---|---|---|---|
| j.bmc.2008.09.018.pdf | 356.5 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
| DCフィールド | 値 | 言語 |
|---|---|---|
| dc.contributor.author | Nishikawa, Hiroki | en |
| dc.contributor.author | Oishi, Shinya | en |
| dc.contributor.author | Fujita, Mizuno | en |
| dc.contributor.author | Watanabe, Kentaro | en |
| dc.contributor.author | Tokiwa, Rei | en |
| dc.contributor.author | Ohno, Hiroaki | en |
| dc.contributor.author | Kodama, Eiichi | en |
| dc.contributor.author | Izumi, Kazuki | en |
| dc.contributor.author | Kajiwara, Keiko | en |
| dc.contributor.author | Naitoh, Takeshi | en |
| dc.contributor.author | Matsuoka, Masao | en |
| dc.contributor.author | Otaka, Akira | en |
| dc.contributor.author | Fujii, Nobutaka | en |
| dc.contributor.alternative | 大石, 真也 | ja |
| dc.contributor.alternative | 藤井, 信孝 | ja |
| dc.date.accessioned | 2011-02-16T05:09:48Z | - |
| dc.date.available | 2011-02-16T05:09:48Z | - |
| dc.date.issued | 2008-10-15 | - |
| dc.identifier.issn | 0968-0896 | - |
| dc.identifier.uri | http://hdl.handle.net/2433/137210 | - |
| dc.description.abstract | Emergence of multi-drug resistant HIV-1 is a serious problem for AIDS treatment. Recently, the virus-cell membrane fusion process has been identified as a promising target for the development of novel drugs against these resistant variants. In this study, we identified a 29-residue peptide fusion inhibitor, SC29EK, which shows activity comparable to the previously reported inhibitor SC35EK. Some residues in SC29EK not required for interaction with virus gp41 heptad repeat 1 (HR1) were replaced with a non-proteinogenic amino acid, 2-aminoisobutyric acid (Aib), to stabilize the alpha-helix structure and to provide resistance to peptidases. | en |
| dc.format.mimetype | application/pdf | - |
| dc.language.iso | eng | - |
| dc.publisher | Elsevier BV | en |
| dc.rights | © 2008 Elsevier Ltd | en |
| dc.subject | HIV-1 | en |
| dc.subject | Fusion inhibitor | en |
| dc.subject | α-Helix | en |
| dc.subject | Heptad repeat | en |
| dc.subject.mesh | Amino Acid Sequence | en |
| dc.subject.mesh | Cell Line | en |
| dc.subject.mesh | Circular Dichroism | en |
| dc.subject.mesh | HIV Fusion Inhibitors/chemistry | en |
| dc.subject.mesh | HIV Fusion Inhibitors/pharmacology | en |
| dc.subject.mesh | HIV-1/drug effects | en |
| dc.subject.mesh | Humans | en |
| dc.subject.mesh | Molecular Sequence Data | en |
| dc.subject.mesh | Protein Denaturation | en |
| dc.title | Identification of minimal sequence for HIV-1 fusion inhibitors. | en |
| dc.type | journal article | - |
| dc.type.niitype | Journal Article | - |
| dc.identifier.ncid | AA10938083 | - |
| dc.identifier.jtitle | Bioorganic & medicinal chemistry | en |
| dc.identifier.volume | 16 | - |
| dc.identifier.issue | 20 | - |
| dc.identifier.spage | 9184 | - |
| dc.identifier.epage | 9187 | - |
| dc.relation.doi | 10.1016/j.bmc.2008.09.018 | - |
| dc.textversion | publisher | - |
| dc.identifier.pmid | 18819810 | - |
| dcterms.accessRights | open access | - |
| dc.identifier.pissn | 0968-0896 | - |
| 出現コレクション: | 学術雑誌掲載論文等 | |
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