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dc.contributor.author | Sakamoto, Masayuki | en |
dc.contributor.author | Imayoshi, Itaru | en |
dc.contributor.author | Ohtsuka, Toshiyuki | en |
dc.contributor.author | Yamaguchi, Masahiro | en |
dc.contributor.author | Mori, Kensaku | en |
dc.contributor.author | Kageyama, Ryoichiro | en |
dc.contributor.alternative | 影山, 龍一郎 | ja |
dc.contributor.alternative | 坂本, 雅行 | ja |
dc.date.accessioned | 2011-05-06T02:32:26Z | - |
dc.date.available | 2011-05-06T02:32:26Z | - |
dc.date.issued | 2011-05-02 | - |
dc.identifier.citation | Sakamoto M, Imayoshi I, Ohtsuka T, Yamaguchi M, Mori K, Kageyama R. Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. Proc Natl Acad Sci U S A. 2011 May 2. | - |
dc.identifier.issn | 0027-8424 | - |
dc.identifier.uri | http://hdl.handle.net/2433/139551 | - |
dc.description | 成体脳におけるニューロン新生は先天的な匂い応答に必要.京都大学プレスリリース.2011-05-03. | ja |
dc.description.abstract | Although the functional significance of adult neurogenesis in hippocampal-dependent learning and memory has been well documented, the role of such neurogenesis in olfactory activity is rather obscure. To understand the significance of adult neurogenesis in olfactory functions, we genetically ablated newly born neurons by using tamoxifen-treated Nestin-CreER(T2);neuron-specific enolase-diphtheria toxin fragment A (NSE-DTA) mice. In these mice, tamoxifen-inducible Cre recombinase allows the NSE (Eno2) gene to drive DTA expression in differentiating neurons, leading to the efficient ablation of newly born neurons in the forebrain. These mutant mice were capable of discriminating odors as competently as control mice. Strikingly, although control and mutant mice frequently showed freezing behaviors to a fox scent, a predator odor, mutant mice approached this odor when they were conditioned to associate the odor with a reward, whereas control mice did not approach the odor. Furthermore, although mutant males and females showed normal social recognition behaviors to other mice of a different sex, mutant males displayed deficits in male-male aggression and male sexual behaviors toward females, whereas mutant females displayed deficits in fertility and nurturing, indicating that sex-specific activities, which are known to depend on olfaction, are impaired. These results suggest that continuous neurogenesis is required for predator avoidance and sex-specific responses that are olfaction dependent and innately programmed. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | The National Academy of Sciences | en |
dc.rights | ©2011 by the National Academy of Sciences | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | adult neurogenesis | en |
dc.subject | olfactory bulb | en |
dc.subject | innate olfactory response | en |
dc.subject | predator avoidance | en |
dc.subject | gender-specific response | en |
dc.subject | transgenic mouse | en |
dc.title | Continuous neurogenesis in the adult forebrain is required for innate olfactory responses. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA10808769 | - |
dc.identifier.jtitle | Proceedings of the National Academy of Sciences of the United States of America | en |
dc.relation.doi | 10.1073/pnas.1018782108 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21536899 | - |
dc.relation.url | http://www.pnas.org/content/early/2011/04/28/1018782108.full.pdf+html | - |
dc.relation.url | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/110503_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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