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タイトル: | ホルモン不応性前立腺癌に対するドセタキセル/UFT療法 |
その他のタイトル: | Combination Chemotherapy of Docetaxel and UFT Against Hormone Refractory Prostate Cancer |
著者: | 島崎, 猛夫 宮澤, 克人 森山, 学 田中, 達朗 佐藤, 到 中谷, 直喜 中島, 日出夫 久保, 杏奈 鈴木, 孝治 元雄, 良治 |
著者名の別形: | Shimasaki, Takeo Miyazawa, Katsuhito Moriyama, Manabu Tanaka, Tatsuro Sato, Itaru Nakaya, Naoki Nakajima, Hideo Kubo, Anna Suzuki, Koji Motoo, Yoshiharu |
キーワード: | Hormone-refractory prostate cancer Docetaxel UFT |
発行日: | 31-Mar-2011 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 57 |
号: | 3 |
開始ページ: | 163 |
終了ページ: | 166 |
抄録: | Docetaxel-based chemotherapy has been shown to be effective and well tolerated by Japanese patients with metastatic hormone-refractory prostate cancer (HRPC). This study was undertaken to assess the feasibility of docetaxel in combination with UFT (a combination of tegafur and uracil) in Japanese patients with HRPC. Ten patients aged 60-86 years with HRPC, who were pre-treated with hormonal therapy and expected to have more than 3 month survival and without major organ dysfunction, were included in this study. Treatment consisted of docetaxel 70 mg/m2 every 3 weeks plus UFT 260 mg/m2 /day. The primary end point was prostate-specific antigen (PSA) response, and the secondary end points included progression-free survival and toxicity. Nine patients were evaluable for efficacy and toxicity. The PSA response rate was 50% (1 CR and 4 PR). The most common non-hematological adverse events (of any grade) possibly related to treatment were neutropenia and anorexia. Grade 3/4 neutropenia and anorexia occurred in 50 and 20% of patients, respectively. The combination of docetaxel and UFT was feasible and active in Japanese patients with HRPC, with a manageable adverse-event profile similar to that observed in lung cancer chemotherapy. |
著作権等: | 許諾条件により本文は2012-04-01に公開 |
URI: | http://hdl.handle.net/2433/139598 |
PubMed ID: | 21586891 |
出現コレクション: | Vol.57 No.3 |
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