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タイトル: | Analysis of Gene Expression in a Human-derived Glial Cell Line Exposed to 2.45 GHz Continuous Radiofrequency Electromagnetic Fields |
著者: | SAKURAI, Tomonori KIYOKAWA, Tomoko NARITA, Eijiro SUZUKI, Yukihisa TAKI, Masao MIYAKOSHI, Junji |
著者名の別形: | 宮越, 順二 |
発行日: | 2011 |
出版者: | Japan Radiation Research Society |
誌名: | Journal of Radiation Research |
巻: | 52 |
号: | 2 |
開始ページ: | 185 |
終了ページ: | 192 |
抄録: | The increasing use of mobile phones has aroused public concern regarding the potential health risks of radiofrequency (RF) fields. We investigated the effects of exposure to RF fields (2.45 GHz, continuous wave) at specific absorption rate (SAR) of 1, 5, and 10 W/kg for 1, 4, and 24 h on gene expression in a normal human glial cell line, SVGp12, using DNA microarray. Microarray analysis revealed 23 assigned gene spots and 5 non-assigned gene spots as prospective altered gene spots. Twenty-two genes out of the 23 assigned gene spots were further analyzed by reverse transcription-polymerase chain reaction to validate the results of microarray, and no significant alterations in gene expression were observed. Under the experimental conditions used in this study, we found no evidence that exposure to RF fields affected gene expression in SVGp12 cells. |
著作権等: | (c) 2011 by Journal of Radiation Research Editorial Committee 本文データは学協会の許諾に基づきCiNiiから複製したものである |
URI: | http://hdl.handle.net/2433/139738 |
DOI(出版社版): | 10.1269/jrr.10116 |
PubMed ID: | 21343680 |
出現コレクション: | 学術雑誌掲載論文等 |
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