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j.febslet.2011.03.014.pdf | 468.76 kB | Adobe PDF | 見る/開く |
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DCフィールド | 値 | 言語 |
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dc.contributor.author | Yamaguchi, Takahiro | en |
dc.contributor.author | Matsuzaki, Katsumi | en |
dc.contributor.author | Hoshino, Masaru | en |
dc.contributor.alternative | 星野, 大 | ja |
dc.date.accessioned | 2011-05-12T01:04:57Z | - |
dc.date.available | 2011-05-12T01:04:57Z | - |
dc.date.issued | 2011-04-06 | - |
dc.identifier.issn | 0014-5793 | - |
dc.identifier.uri | http://hdl.handle.net/2433/139746 | - |
dc.description.abstract | A detailed analysis of the NMR spectra of amyloid-β (Aβ) peptide revealed a decrease in signal intensity at higher temperature, due to a reversible conformational change of the molecule. Although peak intensity did not depend on peptide concentrations, the intensity in the region from D23 to A30 depended significantly on temperature. During the early stages of Aβ aggregation, each molecule might adopt transiently a turn conformation at around D23-A30, which converts mutually with a random coil. Stabilization of a turn by further conformational change and/or molecular association would lead to the formation of a "nucleus" for amyloid fibrils. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier BV | en |
dc.rights | © 2011 Federation of European Biochemical Societies Published by Elsevier B.V. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | NMR | en |
dc.subject | Amyloid fibril formation | en |
dc.subject | Conformational change | en |
dc.subject | Chemical exchange | en |
dc.title | Transient formation of intermediate conformational states of amyloid-β peptide revealed by heteronuclear magnetic resonance spectroscopy. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00642943 | - |
dc.identifier.jtitle | FEBS letters | en |
dc.identifier.volume | 585 | - |
dc.identifier.issue | 7 | - |
dc.identifier.spage | 1097 | - |
dc.identifier.epage | 1102 | - |
dc.relation.doi | 10.1016/j.febslet.2011.03.014 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21402073 | - |
dcterms.accessRights | open access | - |
dc.identifier.pissn | 0014-5793 | - |
dc.identifier.eissn | 1873-3468 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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