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タイトル: Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus.
著者: Doi, Masao  kyouindb  KAKEN_id
Ishida, Atsushi
Miyake, Akiko
Sato, Miho
Komatsu, Rie
Yamazaki, Fumiyoshi
Kimura, Ikuo
Tsuchiya, Soken
Kori, Hiroshi
Seo, Kazuyuki
Yamaguchi, Yoshiaki  kyouindb  KAKEN_id
Matsuo, Masahiro
Fustin, Jean-Michel  kyouindb  KAKEN_id
Tanaka, Rina
Santo, Yasuko
Yamada, Hiroyuki
Takahashi, Yukari
Araki, Michihiro
Nakao, Kazuki
Aizawa, Shinichi
Kobayashi, Masaki
Obrietan, Karl
Tsujimoto, Gozoh
Okamura, Hitoshi
著者名の別形: 土居, 雅夫
岡村, 均
発行日: 24-May-2011
出版者: Nature Publishing Group
引用: Doi M, Ishida A, Miyake A, Sato M, Komatsu R, Yamazaki F, Kimura I, Tsuchiya S, Kori H, Seo K, Yamaguchi Y, Matsuo M, Fustin JM, Tanaka R, Santo Y, Yamada H, Takahashi Y, Araki M, Nakao K, Aizawa S, Kobayashi M, Obrietan K, Tsujimoto G, Okamura H. Circadian regulation of intracellular G-protein signalling mediates intercellular synchrony and rhythmicity in the suprachiasmatic nucleus. Nat Commun. 2011;2:327.
誌名: Nature communications
巻: 2
論文番号: 327
抄録: Synchronous oscillations of thousands of cellular clocks in the suprachiasmatic nucleus (SCN), the circadian centre, are coordinated by precisely timed cell-cell communication, the principle of which is largely unknown. Here we show that the amount of RGS16 (regulator of G protein signalling 16), a protein known to inactivate Gαi, increases at a selective circadian time to allow time-dependent activation of intracellular cyclic AMP signalling in the SCN. Gene ablation of Rgs16 leads to the loss of circadian production of cAMP and as a result lengthens circadian period of behavioural rhythm. The temporally precise regulation of the cAMP signal by clock-controlled RGS16 is needed for the dorsomedial SCN to maintain a normal phase-relationship to the ventrolateral SCN. Thus, RGS16-dependent temporal regulation of intracellular G protein signalling coordinates the intercellular synchrony of SCN pacemaker neurons and thereby defines the 24 h rhythm in behaviour.
記述: 細胞内G蛋白質シグナルの仕分けが生体リズムのタイミングを決める. 京都大学プレスリリース. 2011-05-25.
著作権等: © 2011 Nature Publishing Group
This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/
URI: http://hdl.handle.net/2433/141786
DOI(出版社版): 10.1038/ncomms1316
PubMed ID: 21610730
関連リンク: http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/110525_2.htm
出現コレクション:学術雑誌掲載論文等

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