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DCフィールド | 値 | 言語 |
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dc.contributor.author | Sumi, Shoichiro | en |
dc.contributor.alternative | 角, 昭一郎 | ja |
dc.date.accessioned | 2011-07-07T02:09:11Z | - |
dc.date.available | 2011-07-07T02:09:11Z | - |
dc.date.issued | 2011-01 | - |
dc.identifier.issn | 1868-6982 | - |
dc.identifier.uri | http://hdl.handle.net/2433/141997 | - |
dc.description.abstract | Recent advances in pancreas organogenesis have greatly improved the understanding of cell lineage from inner cell mass to fully differentiated β-cells. Based upon such knowledge, insulin-producing cells similar to β-cells to a certain extent have been generated from various cell sources including embryonic stem cells (ESCs) and induced pluripotent stem (iPS) cells, although fully differentiated cells comparable to β-cells are not yet available. The bioartificial pancreas is a therapeutic approach to enable allo- and xenotransplantation of islets without immune suppression. Among several types of bioartificial pancreases (BAPs), micro-encapsulated porcine islets are already in use in clinical trials and may, perhaps, replace islet transplantation in the near future. Some types of bioartificial pancreas such as macro-encapsulation are also useful for keeping transplanted cells enclosed in case retrieval is necessary. Therefore, early clinical applications of artificially generated β-like cells, especially those from ESCs or iPS cells, will be considered in combination with retrievable BAPs. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Japanese Society of Hepato-Biliary-Pancreatic Surgery and Springer | en |
dc.rights | The final publication is available at www.springerlink.com | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Diabetes mellitus | en |
dc.subject | β-cells | en |
dc.subject | Pancreas | en |
dc.subject | Insulin | en |
dc.subject | Islets of Langerhans | en |
dc.subject.mesh | Animals | en |
dc.subject.mesh | Biological Markers | en |
dc.subject.mesh | Cell Differentiation | en |
dc.subject.mesh | Cell Lineage | en |
dc.subject.mesh | Cells, Cultured/cytology | en |
dc.subject.mesh | Cells, Cultured/drug effects | en |
dc.subject.mesh | Cells, Cultured/transplantation | en |
dc.subject.mesh | Diabetes Mellitus/surgery | en |
dc.subject.mesh | Diabetes Mellitus, Experimental/surgery | en |
dc.subject.mesh | Gene Expression Regulation, Developmental | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Insulin-Secreting Cells/cytology | en |
dc.subject.mesh | Islets of Langerhans/cytology | en |
dc.subject.mesh | Islets of Langerhans/physiology | en |
dc.subject.mesh | Islets of Langerhans Transplantation | en |
dc.subject.mesh | Organogenesis/physiology | en |
dc.subject.mesh | Pancreas/cytology | en |
dc.subject.mesh | Pancreas/embryology | en |
dc.subject.mesh | Pancreas, Artificial | en |
dc.subject.mesh | Regeneration | en |
dc.subject.mesh | Stem Cell Transplantation | en |
dc.subject.mesh | Swine | en |
dc.subject.mesh | Transcription Factors/physiology | en |
dc.title | Regenerative medicine for insulin deficiency: creation of pancreatic islets and bioartificial pancreas. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Journal of hepato-biliary-pancreatic sciences | en |
dc.identifier.volume | 18 | - |
dc.identifier.issue | 1 | - |
dc.identifier.spage | 6 | - |
dc.identifier.epage | 12 | - |
dc.relation.doi | 10.1007/s00534-010-0303-3 | - |
dc.textversion | author | - |
dc.identifier.pmid | 20589399 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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