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タイトル: | ゾレドロン酸が有効であった骨シンチ陰性の播種性骨髄癌症を伴う前立腺癌の1例 |
その他のタイトル: | A Case of Prostate Cancer with Disseminated Carcinomatosis of Bone Marrow which Responded to Zoledronic Acid |
著者: | 加藤, 敬司 長濱, 寛二 八木橋, 祐亮 山本, 雅一 金丸, 洋史 平田, 大仁 |
著者名の別形: | Kato, Keiji Nagahama, Kanji Yagibashi, Yusuke Yamamoto, Masakazu Kanamaru, Hiroshi Hirata, Hirokazu |
キーワード: | Prostate cancer Disseminated carcinomatosis of bone marrow Zoledronic acid |
発行日: | Jun-2011 |
出版者: | 泌尿器科紀要刊行会 |
誌名: | 泌尿器科紀要 |
巻: | 57 |
号: | 6 |
開始ページ: | 331 |
終了ページ: | 335 |
抄録: | A 76-year-old man underwent radical prostatectomy under the diagnosis of stage C prostate cancer (cT3bN0M0, Gleason score 3+4) in 1999. Endocrine treatment for postoperative biochemical failure started in 2001. He was admitted to our hospital because of general fatigue and multiple bone pain with a prostate specific antigen (PSA) level of 1, 141 ng/ml in August 2009. On admission, no metastasis was detected on bone scintigraphy or computed tomography. Bone marrow biopsy was finally performed for the assessment of bone metastasis after PSA further increased to 8, 679 ng/ml with the manifestation of severe anemia and thrombocytopenia. The biopsy findings disclosed disseminated carcinomatosis of bone marrow (DCBM). Treatment with Zoledronic acid (ZA) not only mitigated bone pain, but also rapidly improved of PSA and hematological findings. Although the prognosis of a patient with DCBM is generally considered to be very poor, ZA contributed to the improvement for the survival of the patient in the present case. |
著作権等: | 許諾条件により本文は2012-07-01に公開 |
URI: | http://hdl.handle.net/2433/143299 |
PubMed ID: | 21795838 |
出現コレクション: | Vol.57 No.6 |
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