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Title: ゾレドロン酸が有効であった骨シンチ陰性の播種性骨髄癌症を伴う前立腺癌の1例
Other Titles: A Case of Prostate Cancer with Disseminated Carcinomatosis of Bone Marrow which Responded to Zoledronic Acid
Authors: 加藤, 敬司  KAKEN_name
長濱, 寛二  KAKEN_name
八木橋, 祐亮  KAKEN_name
山本, 雅一  KAKEN_name
金丸, 洋史  KAKEN_name
平田, 大仁  KAKEN_name
Author's alias: Kato, Keiji
Nagahama, Kanji
Yagibashi, Yusuke
Yamamoto, Masakazu
Kanamaru, Hiroshi
Hirata, Hirokazu
Keywords: Prostate cancer
Disseminated carcinomatosis of bone marrow
Zoledronic acid
Issue Date: Jun-2011
Publisher: 泌尿器科紀要刊行会
Journal title: 泌尿器科紀要
Volume: 57
Issue: 6
Start page: 331
End page: 335
Abstract: A 76-year-old man underwent radical prostatectomy under the diagnosis of stage C prostate cancer (cT3bN0M0, Gleason score 3+4) in 1999. Endocrine treatment for postoperative biochemical failure started in 2001. He was admitted to our hospital because of general fatigue and multiple bone pain with a prostate specific antigen (PSA) level of 1,141 ng/ml in August 2009. On admission, no metastasis was detected on bone scintigraphy or computed tomography. Bone marrow biopsy was finally performed for the assessment of bone metastasis after PSA further increased to 8,679 ng/ml with the manifestation of severe anemia and thrombocytopenia. The biopsy findings disclosed disseminated carcinomatosis of bone marrow (DCBM). Treatment with Zoledronic acid (ZA) not only mitigated bone pain, but also rapidly improved of PSA and hematological findings. Although the prognosis of a patient with DCBM is generally considered to be very poor, ZA contributed to the improvement for the survival of the patient in the present case.
Rights: 許諾条件により本文は2012-07-01に公開
PubMed ID: 21795838
Appears in Collections:Vol.57 No.6

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