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j.freeradbiomed.2011.05.025.pdf | 222.26 kB | Adobe PDF | 見る/開く |
タイトル: | Inhibition of surgical trauma-enhanced peritoneal dissemination of tumor cells by human catalase derivatives in mice. |
著者: | Nishizaki, Chika Nishikawa, Makiya Yata, Tomoya Yamada, Toshiyuki Takahashi, Yuki https://orcid.org/0000-0002-8772-2772 (unconfirmed) Oku, Masahide https://orcid.org/0000-0001-7506-6184 (unconfirmed) Yurimoto, Hiroya https://orcid.org/0000-0001-7506-6184 (unconfirmed) Sakai, Yasuyoshi Nakanishi, Kenji Takakura, Yoshinobu https://orcid.org/0000-0002-7359-2647 (unconfirmed) |
著者名の別形: | 西川, 元也 |
キーワード: | Recombinant human catalase Surgical trauma Tumor metastasis Reactive oxygen species Free radicals |
発行日: | 1-Aug-2011 |
出版者: | Elsevier BV |
誌名: | Free radical biology & medicine |
巻: | 51 |
号: | 3 |
開始ページ: | 773 |
終了ページ: | 779 |
抄録: | Surgical trauma, which is inevitably associated with the surgical removal of cancer, has been reported to accelerate tumor metastasis. The close association of reactive oxygen species with the trauma and tumor metastasis supports the possibility of using antioxidants for the inhibition of metastasis. To inhibit surgical trauma-enhanced peritoneal dissemination, human catalase (hCAT) derivatives, i.e., hCAT-nona-arginine peptide (hCAT-R9) and hCAT-albumin-binding peptide (hCAT-ABP), were designed to increase the retention time of the antioxidant enzyme in the abdominal cavity after intraperitoneal administration. Both (125)I-labeled derivatives showed significantly prolonged retention in the cavity compared to (125)I-hCAT. Cauterization of the cecum of mice with a hot iron, an experimental model of surgical trauma, induced abdominal adhesions. In addition, cauterization followed by colon26 tumor cell inoculation increased lipid peroxidation in the cecum and mRNA expression of molecules associated with tissue repair/adhesion and inflammation in the peritoneum. hCAT derivatives significantly suppressed the increased mRNA expression. The cauterization also increased the number of tumor cells in the abdominal organs, and the number was significantly reduced by hCAT-R9 or hCAT-ABP. These results indicate that hCAT-R9 and hCAT-ABP, both of which have a long retention time in the peritoneal cavity, can be effective at inhibiting surgery-induced peritoneal metastasis. |
著作権等: | © 2011 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/143690 |
DOI(出版社版): | 10.1016/j.freeradbiomed.2011.05.025 |
PubMed ID: | 21664457 |
出現コレクション: | 学術雑誌掲載論文等 |
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