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タイトル: 前立腺針生検における塩酸トラマドールの経口投与による疼痛緩和の二重盲検ランダム化試験による検討
その他のタイトル: Analgesic Effect of Oral Tramadol on Transrectal Ultrasound-Guided Needle Biopsy of the Prostate in a Randomized Double-Blind Study
著者: 能見, 勇人  KAKEN_name
東, 治人  KAKEN_name
瀬川, 直樹  KAKEN_name
稲元, 輝生  KAKEN_name
高原, 健  KAKEN_name
小村, 和正  KAKEN_name
小山, 耕平  KAKEN_name
右梅, 貴信  KAKEN_name
勝岡, 洋治  KAKEN_name
著者名の別形: Nomi, Hayahito
Azuma, Haruhito
Segawa, Naoki
Inamoto, Teruo
Takahara, Kiyoshi
Komura, Kazumasa
Koyama, Kohei
Ubai, Takanobu
Katsuoka, Yoji
キーワード: Tramadol
Prostate
Needle
Biopsy
Analgesia
発行日: Aug-2011
出版者: 泌尿器科紀要刊行会
誌名: 泌尿器科紀要
巻: 57
号: 8
開始ページ: 425
終了ページ: 428
抄録: A total of 121 Japanese patients scheduled for prostate biopsy were randomly and double-blindly assigned to be given a single oral dose of 100 mg Tramadol mixed with 20 ml of sugar syrup or placebo, 30 minutes before the procedure. Pain severity was measured by verbal rating scale (VRS) and visual analog scales (VAS). We also analyzed cardio-respiratory parameters and complications. Of 121 patients, 117 replied validly to VRS and VAS ; and 91 of 117 patients replied to the cohort questionnaire for analysis of the late disorder, patient’s impression, prolonged pain and past history of hemorrhoid treatment. Tramadol showed no significant effect on pain severity indicated by VRS and VAS, and no change in cardiorespiratory parameters. Furthermore, 70 patients without a history of hemorrhoid treatment, showed no significant analgesic benefits of Tramadol during the biopsy. In total, 3 patients had side effects of vomiting (CTCAE : grade 1)6), which subsided spontaneously. The oral administration of a single dose of 100 mg Tramadol 30 minutes before a transrectal needle biopsy of the prostate was safe, but was not effective to calm down the pain severity.
著作権等: 許諾条件により本文は2012-09-01に公開
URI: http://hdl.handle.net/2433/145947
PubMed ID: 21894078
出現コレクション:Vol.57 No.8

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