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j.bbrc.2011.06.189.pdf | 2.13 MB | Adobe PDF | 見る/開く |
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dc.contributor.author | Ukai, Yuuta | en |
dc.contributor.author | Kishimoto, Tomoyuki | en |
dc.contributor.author | Ohdate, Takumi | en |
dc.contributor.author | Izawa, Singo | en |
dc.contributor.author | Inoue, Yoshiharu | en |
dc.contributor.alternative | 井上, 善晴 | ja |
dc.date.accessioned | 2011-09-09T02:11:29Z | - |
dc.date.available | 2011-09-09T02:11:29Z | - |
dc.date.issued | 2011-08 | - |
dc.identifier.issn | 0006-291X | - |
dc.identifier.uri | http://hdl.handle.net/2433/145971 | - |
dc.description.abstract | Gpx2, one of three glutathione peroxidase homologs (Gpx1, Gpx2, and Gpx3) in Saccharomyces cerevisiae, is an atypical 2-Cys peroxiredoxin that prefers to use thioredoxin as a reducing agent in vitro. Despite Gpx2 being an antioxidant, no obvious phenotype of gpx2Δ mutant cells in terms of oxidative stress has yet been found. To gain a clue as to Gpx2’s physiological function in vivo, here we identify its intracellular distribution. Gpx2 was found to exist in the cytoplasm and mitochondria. In mitochondria, Gpx2 was associated with the outer membrane of the cytoplasmic-side, as well as the inner membrane of the matrix-side. The redox state of the mitochondrial Gpx2 was regulated by Trx1 and Trx2 (cytoplasmic thioredoxin), and by Trx3 (mitochondrial matrix thioredoxin). In addition, we found that the disruption of GPX2 reduced the sporulation efficiency of diploid cells. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2011 Elsevier Inc. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.subject | Glutathione peroxidase | en |
dc.subject | Saccharomyces cerevisiae | en |
dc.subject | Peroxiredoxin | en |
dc.subject | Mitochondria | en |
dc.subject | Sporulation | en |
dc.title | Glutathione peroxidase 2 in Saccharomyces cerevisiae is distributed in mitochondria and involved in sporulation | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00564395 | - |
dc.identifier.jtitle | Biochemical and Biophysical Research Communications | en |
dc.identifier.volume | 411 | - |
dc.identifier.issue | 3 | - |
dc.identifier.spage | 580 | - |
dc.identifier.epage | 585 | - |
dc.relation.doi | 10.1016/j.bbrc.2011.06.189 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21763276 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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