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Title: Influence of Coronary Risk Factors on Coronary Events in Japanese High-Risk Hypertensive Patients
Authors: Ueshima, Kenji  kyouindb  KAKEN_id
Oba, Koji
Yasuno, Shinji  kyouindb  KAKEN_id
Fujimoto, Akira
Tanaka, Shiro  kyouindb  KAKEN_id  orcid (unconfirmed)
Ogihara, Toshio
Saruta, Takao
Nakao, Kazuwa
Author's alias: 上嶋, 健治
Keywords: Coronary event
Coronary risk factor
Issue Date: 22-Sep-2011
Citation: Kenji Ueshima, Koji Oba, Shinji Yasuno, Akira Fujimoto, Shiro Tanaka, Toshio Ogihara, Takao Saruta and Kazuwa Nakao "Influence of Coronary Risk Factors on Coronary Events in Japanese High-Risk Hypertensive Patients"; Circ J. Vol. 75. 2411-2416. (2011) .
Journal title: Circulation Journal
Volume: 75
Issue: 10
Start page: 2411
End page: 2416
Abstract: Background: The Candesartan Antihypertensive Survival Evaluation in Japan (CASE-J) trial was conducted to compare the effects of candesartan and amlodipine on cardiovascular events in Japanese high-risk hypertensive patients. The aim of the present subanalysis was to evaluate the influence of coronary risk factors on coronary events in these patients as an observational study irrespective of allocated drugs. Methods and Results: The adjusted hazard ratios (HRs) of the association of baseline risk factors including gender, age, allocated drugs, body mass index, systolic/diastolic blood pressure (SBP/DBP), diabetes mellitus (DM), hyperlipidemia (HL), smoking, left ventricular hypertrophy, previous ischemic heart disease (IHD), previous cerebrovascular events, and chronic kidney disease (CKD) with coronary events in 4,703 patients who were enrolled in the CASE-J trial, were examined. The coronary events occurred in 83 patients, and were significantly associated with previous IHD, DM, male sex, CKD, and low DBP. Significant predictors were previous IHD (HR, 3.89), DM (HR, 3.10), male sex (HR, 1.81), CKD (HR, 1.60), and low DBP (HR, 1.36), respectively. In 4,107 patients without pre-vious IHD, DM (HR, 4.88), HL (HR, 2.67), and DBP (HR, 1.39) were significantly associated with the risk of coronary events, while male sex (HR, 3.03), CKD (HR, 2.44), and DM (HR, 2.15) were in 596 patients with previous IHD. Conclusions: DM is the important factor in both primary and secondary prevention of coronary events. Comprehensive risk management including surveillance of DM, CKD and HL is needed for preventing coronary events, in addition to blood pressure control. (Circ J 2011; 75: 2411-2416)
DOI(Published Version): 10.1253/circj.CJ-10-1161
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