遺伝性非ポリポーシス大腸癌に異時性両側上部尿路癌と膀胱癌を合併した1例

Abstract

A 40-year-old man had undergone right hemicolectomy and sigmoidectomy under the diagnosis of ascending andsigmoidcolon cancer andright nephroureterectomy under the diagnosis of right ureteral cancer, in 1997andin 2002, respectively. In 2007, He visitedour hospital with a complaint of bloody stool andhematuria. Colon fiberscopy, ureteropelvicscopy andcystoscopy demonstratedcolon cancer, left renal pelvis cancer and bladder cancer, respectively, as diagnosed by biopsies, followed by restative colectomy, left nephroureterectomy andcystectomy. The final histopathological examination showedwell differentiated adenocarcinoma (pSM) in the colon, and urothelial carcinoma in the left renal pelvis (pT2) and the bladder (pT1). Since his uncle andeld er brother hadsufferedfrom stomach cancer andcolon cancer, respectively, he was diagnosed with hereditary nonpolyposis colorectal cancer (HNPCC : Lynch syndrome). He has been well doing without recurrence for 3 years after the surgery.