ダウンロード数: 545
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
000333212.pdf | 294.94 kB | Adobe PDF | 見る/開く |
タイトル: | Clinical characteristics of non-B non-C hepatocellular carcinoma: a single-center retrospective study. |
著者: | Kim, Soo Ki Marusawa, Hiroyuki Eso, Yuji https://orcid.org/0000-0003-4426-1491 (unconfirmed) Nishikawa, Hiroki Ueda, Yoshihide https://orcid.org/0000-0003-3196-3494 (unconfirmed) Kita, Ryuichi Kimura, Toru Chiba, Tsutomu Osaki, Yukio Kudo, Masatoshi |
著者名の別形: | 金, 秀基 丸澤, 宏之 |
キーワード: | Liver cancer Non-B non-C hepatocellular carcinoma Nonalcoholic steatohepatitis Alcohol Diabetes |
発行日: | Dec-2011 |
出版者: | Karger |
誌名: | Digestion |
巻: | 84 Suppl 1 |
開始ページ: | 43 |
終了ページ: | 49 |
抄録: | Background/Aims: To clarify risk factors and clinical features of both hepatitis B surface antigen and anti-HCV negative hepatocellular carcinoma (NBNC-HCC). Methods: HCC patients (n = 1, 109) diagnosed at a single center were categorized based on the presence of serum hepatitis B surface antigen and HCVAb. Clinical characteristics of 127 NBNC-HCC patients were evaluated. Results: NBNC-HCC patients were stratified as those with alcoholic liver disease (ALD-HCC, n = 42) and alcohol-unrelated liver disease (non-ALD-HCC, n = 85). Compared with the ALD-HCC group, the non-ALD-HCC group had a higher prevalence of diabetes (p = 0.015), larger tumor size (p = 0.007), and higher tumor marker levels (p = 0.014). Liver function results were significantly worse in ALD-HCC than in non-ALD-HCC. Although the ALD-HCC group had a higher tendency toward recurrence than the non-ALD-HCC group, survival rates were similar between groups (p = 0.352). Conclusion: Alcohol consumption was the most common etiologic factor for NBNC-HCC, and diabetes may be related to the development of HCC in non-ALD-HCC patients. Non-ALD-HCC tended to be diagnosed at a more advanced stage, whereas liver function was worse, and tumor recurrence rate was higher in ALD-HCC patients. Further examination of the risk factors and establishment of a precise surveillance system are necessary for early diagnosis and the development of curative therapies for NBNC-HCC. |
著作権等: | © 2011 S. Karger AG, Basel This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/152377 |
DOI(出版社版): | 10.1159/000333212 |
PubMed ID: | 22156485 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。