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Title: A DNA-based molecular motor that can navigate a network of tracks
Authors: Wickham, Shelley F. J.
Bath, Jonathan
Katsuda, Yousuke
Endo, Masayuki  KAKEN_id
Hidaka, Kumi
Sugiyama, Hiroshi  kyouindb  KAKEN_id  orcid (unconfirmed)
Turberfield, Andrew J.
Author's alias: 杉山, 弘
遠藤, 政幸
Issue Date: 22-Jan-2012
Publisher: Nature Publishing Group
Citation: Shelley F. J. Wickham, Jonathan Bath, YousukeKatsuda, Masayuki Endo, Kumi Hidaka, Hiroshi Sugiyama, Andrew J. Turberfield. A DNA-based molecular motor that can navigate anetwork of tracks. Nature Nanotechnology (2012), DOI: 10.1038/NNANO.2011.253
Journal title: Nature Nanotechnology
Volume: 7
Issue: 3
Start page: 169
End page: 173
Abstract: Synthetic molecular motors can be fuelled by the hydrolysis1, 2, 3, 4 or hybridization5, 6, 7, 8, 9, 10, 11 of DNA. Such motors can move autonomously1, 2, 3, 4, 7, 11 and programmably12, and long-range transport has been observed on linear tracks13, 14. It has also been shown that DNA systems can compute8, 15, 16, 17, 18. Here, we report a synthetic DNA-based system that integrates long-range transport and information processing. We show that the path of a motor through a network of tracks containing four possible routes can be programmed using instructions that are added externally or carried by the motor itself. When external control is used we find that 87% of the motors follow the correct path, and when internal control is used 71% of the motors follow the correct path. Programmable motion will allow the development of computing networks, molecular systems that can sort and process cargoes according to instructions that they carry, and assembly lines19, 20 that can be reconfigured dynamically in response to changing demands.
Description: DNA分子モーターの動きをナノスケールでコントロールする事に成功-ナノ・メゾ空間での分子ロボットの開発へ-. 京都大学プレスリリース. 2012-01-23.
Rights: © 2012 Macmillan Publishers Limited. All rights reserved.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1038/nnano.2011.253
PubMed ID: 22266636
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