ダウンロード数: 446
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
j.jbiomech.2011.04.012.pdf | 894.77 kB | Adobe PDF | 見る/開く |
タイトル: | Effect of tensile force on the mechanical behavior of actin filaments. |
著者: | Matsushita, Shinji Inoue, Yasuhiro https://orcid.org/0000-0002-1968-8883 (unconfirmed) Hojo, Masaki Sokabe, Masahiro Adachi, Taiji https://orcid.org/0000-0001-5280-4156 (unconfirmed) |
著者名の別形: | 安達, 泰治 |
キーワード: | Actin filament Tensile force Mechanical properties Mechano-chemical interactions Steered molecular dynamics simulation Computational biomechanics Cell mechanics |
発行日: | 3-Jun-2011 |
出版者: | Elsevier Ltd. |
誌名: | Journal of biomechanics |
巻: | 44 |
号: | 9 |
開始ページ: | 1776 |
終了ページ: | 1781 |
抄録: | Actin filaments are the most abundant components of the cellular cytoskeleton, and play critical roles in various cellular functions such as migration, division and shape control. In these activities, mechanical tension causes structural changes in the double-helical structure of the actin filament, which is a key modulator of cytoskeletal reorganization. This study performed large-scale molecular dynamics (MD) and steered MD simulations to quantitatively analyze the effects of tensile force on the mechanical behavior of actin filaments. The results revealed that when a tensile force of 200pN was applied to a filament consisting of 14 actin subunits, the twist angle of the filament decreased by approximately 20°, corresponding to a rotation of approximately -2° per subunit, representing a critical structural change in actin filaments. Based on these structural changes, the variance in filament length and twist angle was found to decrease, leading to increases in extensional and torsional stiffness. Torsional stiffness increased significantly under the tensile condition, and the ratio of filament stiffness under tensile force to that under no external force increased significantly on longer temporal scales. The results obtained from this study contribute to the understanding of mechano-chemical interactions concerning actin dynamics, showing that increased tensile force in the filament prevents actin regulatory proteins from binding to the filament. |
著作権等: | © 2011 Elsevier Ltd. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/152437 |
DOI(出版社版): | 10.1016/j.jbiomech.2011.04.012 |
PubMed ID: | 21536289 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。