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dc.contributor.author | Kim, Young-il | en |
dc.contributor.author | Hirai, Shizuka | en |
dc.contributor.author | Goto, Tsuyoshi | en |
dc.contributor.author | Ohyane, Chie | en |
dc.contributor.author | Takahashi, Haruya | en |
dc.contributor.author | Tsugane, Taneaki | en |
dc.contributor.author | Konishi, Chiaki | en |
dc.contributor.author | Fujii, Takashi | en |
dc.contributor.author | Inai, Shuji | en |
dc.contributor.author | Iijima, Yoko | en |
dc.contributor.author | Aoki, Koh | en |
dc.contributor.author | Shibata, Daisuke | en |
dc.contributor.author | Takahashi, Nobuyuki | en |
dc.contributor.author | Kawada, Teruo | en |
dc.contributor.alternative | 河田, 照雄 | ja |
dc.contributor.alternative | 金, 英一 | ja |
dc.date.accessioned | 2012-02-10T02:34:04Z | - |
dc.date.available | 2012-02-10T02:34:04Z | - |
dc.date.issued | 2012-02-09 | - |
dc.identifier.citation | Kim Y-i, Hirai S, Goto T, Ohyane C, Takahashi H, et al. (2012) Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice. PLoS ONE 7(2): e31317. doi:10.1371/journal.pone.0031317 | - |
dc.identifier.issn | 1932-6203 | - |
dc.identifier.uri | http://hdl.handle.net/2433/152546 | - |
dc.description | トマトから脂肪肝、血中中性脂肪改善に有効な健康成分を発見:効果を肥満マウスで確認. 京都大学プレスリリース. 2012-02-10. | ja |
dc.description.abstract | Dyslipidemia is a major risk factor for development of several obesity-related diseases. The peroxisome proliferator-activated receptor α (PPARα) is a ligand-activated transcription factor that regulates energy metabolism. Previously, we reported that 9-oxo-10, 12-octadecadienoic acid (9-oxo-ODA) is presented in fresh tomato fruits and acts as a PPARα agonist. In addition to 9-oxo-ODA, we developed that 13-oxo-9, 11-octadecadienoic acid (13-oxo-ODA), which is an isomer of 9-oxo-ODA, is present only in tomato juice. In this study, we explored the possibility that 13-oxo-ODA acts as a PPARα agonist in vitro and whether its effect ameliorates dyslipidemia and hepatic steatosis in vivo. In vitro luciferase assay experiments revealed that 13-oxo-ODA significantly induced PPARα activation; moreover, the luciferase activity of 13-oxo-ODA was stronger than that of 9-oxo-ODA and conjugated linoleic acid (CLA), which is a precursor of 13-oxo-ODA and is well-known as a potent PPARα activator. In addition to in vitro experiment, treatment with 13-oxo-ODA decreased the levels of plasma and hepatic triglycerides in obese KK-Ay mice fed a high-fat diet. In conclusion, our findings indicate that 13-oxo-ODA act as a potent PPARα agonist, suggesting a possibility to improve obesity-induced dyslipidemia and hepatic steatosis. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Public Library of Science | en |
dc.rights | © 2012 Kim et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. | en |
dc.title | Potent PPARα Activator Derived from Tomato Juice, 13-oxo-9,11-Octadecadienoic Acid, Decreases Plasma and Hepatic Triglyceride in Obese Diabetic Mice | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | PLoS ONE | en |
dc.identifier.volume | 7 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | e31317 | - |
dc.relation.doi | 10.1371/journal.pone.0031317 | - |
dc.textversion | publisher | - |
dc.identifier.pmid | 22347463 | - |
dc.relation.url | https://www.kyoto-u.ac.jp/static/ja/news_data/h/h1/news6/2011/120210_1.htm | - |
dc.relation.url | http://dx.plos.org/10.1371/journal.pone.0031317 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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