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dc.contributor.author | Kumeta, Masahiro | en |
dc.contributor.author | Yoshimura, Shige H | en |
dc.contributor.author | Hejna, James | en |
dc.contributor.author | Takeyasu, Kunio | en |
dc.contributor.alternative | 粂田, 昌宏 | ja |
dc.date.accessioned | 2012-02-17T06:41:08Z | - |
dc.date.available | 2012-02-17T06:41:08Z | - |
dc.date.issued | 2012 | - |
dc.identifier.issn | 1687-8876 | - |
dc.identifier.uri | http://hdl.handle.net/2433/153017 | - |
dc.description.abstract | Various nuclear functional complexes contain cytoskeletal proteins as regulatory subunits; for example, nuclear actin participates in transcriptional complexes, and actin-related proteins are integral to chromatin remodeling complexes. Nuclear complexes such as these are involved in both basal and adaptive nuclear functions. In addition to nuclear import via classical nuclear transport pathways or passive diffusion, some large cytoskeletal proteins spontaneously migrate into the nucleus in a karyopherin-independent manner. The balance of nucleocytoplasmic distribution of such proteins can be altered by several factors, such as import versus export, or capture and release by complexes. The resulting accumulation or depletion of the nuclear populations thereby enhances or attenuates their nuclear functions. We propose that such molecular dynamics constitute a form of cytoskeleton-modulated regulation of nuclear functions which is mediated by the translocation of cytoskeletal components in and out of the nucleus. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Hindawi Publishing Corporation | en |
dc.rights | Copyright © 2012 Masahiro Kumeta et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. | en |
dc.title | Nucleocytoplasmic shuttling of cytoskeletal proteins: molecular mechanism and biological significance. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | International journal of cell biology | en |
dc.identifier.volume | 2012 | - |
dc.relation.doi | 10.1155/2012/494902 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 494902 | - |
dc.identifier.pmid | 22229032 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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