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dc.contributor.author | Ichimura, Atsuhiko | en |
dc.contributor.author | Hirasawa, Akira | en |
dc.contributor.author | Poulain-Godefroy, Odile | en |
dc.contributor.author | Bonnefond, Amélie | en |
dc.contributor.author | Hara, Takafumi | en |
dc.contributor.author | Yengo, Loïc | en |
dc.contributor.author | Kimura, Ikuo | en |
dc.contributor.author | Leloire, Audrey | en |
dc.contributor.author | Liu, Ning | en |
dc.contributor.author | Iida, Keiko | en |
dc.contributor.author | Choquet, Hélène | en |
dc.contributor.author | Besnard, Philippe | en |
dc.contributor.author | Lecoeur, Cécile | en |
dc.contributor.author | Vivequin, Sidonie | en |
dc.contributor.author | Ayukawa, Kumiko | en |
dc.contributor.author | Takeuchi, Masato | en |
dc.contributor.author | Ozawa, Kentaro | en |
dc.contributor.author | Tauber, Maithé | en |
dc.contributor.author | Maffeis, Claudio | en |
dc.contributor.author | Morandi, Anita | en |
dc.contributor.author | Buzzetti, Raffaella | en |
dc.contributor.author | Elliott, Paul | en |
dc.contributor.author | Pouta, Anneli | en |
dc.contributor.author | Jarvelin, Marjo-Riitta | en |
dc.contributor.author | Körner, Antje | de |
dc.contributor.author | Kiess, Wieland | en |
dc.contributor.author | Pigeyre, Marie | en |
dc.contributor.author | Caiazzo, Roberto | en |
dc.contributor.author | Van Hul, Wim | en |
dc.contributor.author | Van Gaal, Luc | en |
dc.contributor.author | Horber, Fritz | en |
dc.contributor.author | Balkau, Beverley | en |
dc.contributor.author | Lévy-Marchal, Claire | en |
dc.contributor.author | Rouskas, Konstantinos | en |
dc.contributor.author | Kouvatsi, Anastasia | en |
dc.contributor.author | Hebebrand, Johannes | en |
dc.contributor.author | Hinney, Anke | en |
dc.contributor.author | Scherag, Andre | en |
dc.contributor.author | Pattou, François | en |
dc.contributor.author | Meyre, David | en |
dc.contributor.author | Koshimizu, Taka-Aki | en |
dc.contributor.author | Wolowczuk, Isabelle | en |
dc.contributor.author | Tsujimoto, Gozoh | en |
dc.contributor.author | Froguel, Philippe | en |
dc.contributor.alternative | 辻本, 豪三 | ja |
dc.contributor.alternative | 平澤, 明 | ja |
dc.contributor.alternative | 市村, 敦彦 | ja |
dc.date.accessioned | 2012-03-02T05:28:45Z | - |
dc.date.available | 2012-03-02T05:28:45Z | - |
dc.date.issued | 2012-02-19 | - |
dc.identifier.citation | Ichimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012 Feb 19. doi: 10.1038/nature10798. | - |
dc.identifier.issn | 1476-4687 | - |
dc.identifier.uri | http://hdl.handle.net/2433/153278 | - |
dc.description | 脂肪センサーGPR120が食事性肥満の原因遺伝子であることの発見. 京都大学プレスリリース. 2012-02-20. | ja |
dc.description.abstract | Free fatty acids provide an important energy source as nutrients, and act as signalling molecules in various cellular processes. Several G-protein-coupled receptors have been identified as free-fatty-acid receptors important in physiology as well as in several diseases. GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role in various physiological homeostasis mechanisms such as adipogenesis, regulation of appetite and food preference. Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis. Insulin resistance in such mice is associated with reduced insulin signalling and enhanced inflammation in adipose tissue. In human, we show that GPR120 expression in adipose tissue is significantly higher in obese individuals than in lean controls. GPR120 exon sequencing in obese subjects reveals a deleterious non-synonymous mutation (p.R270H) that inhibits GPR120 signalling activity. Furthermore, the p.R270H variant increases the risk of obesity in European populations. Overall, this study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | ©2012 Macmillan Publishers Limited. All rights reserved | en |
dc.rights | 許諾条件により本文は2012-08-19に公開. | ja |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.title | Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature | en |
dc.relation.doi | 10.1038/nature10798 | - |
dc.textversion | author | - |
dc.startdate.bitstreamsavailable | 2012-08-19 | - |
dc.identifier.pmid | 22343897 | - |
dc.relation.url | http://www.nature.com/nature/journal/vaop/ncurrent/full/nature10798.html | - |
dc.relation.url | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/120220_1.htm | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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