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dc.contributor.authorIchimura, Atsuhikoja
dc.contributor.authorHirasawa, Akiraja
dc.contributor.authorPoulain-Godefroy, Odileja
dc.contributor.authorBonnefond, Amélieja
dc.contributor.authorHara, Takafumija
dc.contributor.authorYengo, Loïcja
dc.contributor.authorKimura, Ikuoja
dc.contributor.authorLeloire, Audreyja
dc.contributor.authorLiu, Ningja
dc.contributor.authorIida, Keikoja
dc.contributor.authorChoquet, Hélèneja
dc.contributor.authorBesnard, Philippeja
dc.contributor.authorLecoeur, Cécileja
dc.contributor.authorVivequin, Sidonieja
dc.contributor.authorAyukawa, Kumikoja
dc.contributor.authorTakeuchi, Masatoja
dc.contributor.authorOzawa, Kentaroja
dc.contributor.authorTauber, Maithéja
dc.contributor.authorMaffeis, Claudioja
dc.contributor.authorMorandi, Anitaja
dc.contributor.authorBuzzetti, Raffaellaja
dc.contributor.authorElliott, Paulja
dc.contributor.authorPouta, Annelija
dc.contributor.authorJarvelin, Marjo-Riittaja
dc.contributor.authorKörner, Antjeja
dc.contributor.authorKiess, Wielandja
dc.contributor.authorPigeyre, Marieja
dc.contributor.authorCaiazzo, Robertoja
dc.contributor.authorVan Hul, Wimja
dc.contributor.authorVan Gaal, Lucja
dc.contributor.authorHorber, Fritzja
dc.contributor.authorBalkau, Beverleyja
dc.contributor.authorLévy-Marchal, Claireja
dc.contributor.authorRouskas, Konstantinosja
dc.contributor.authorKouvatsi, Anastasiaja
dc.contributor.authorHebebrand, Johannesja
dc.contributor.authorHinney, Ankeja
dc.contributor.authorScherag, Andreja
dc.contributor.authorPattou, Françoisja
dc.contributor.authorMeyre, Davidja
dc.contributor.authorKoshimizu, Taka-Akija
dc.contributor.authorWolowczuk, Isabelleja
dc.contributor.authorTsujimoto, Gozohja
dc.contributor.authorFroguel, Philippeja
dc.contributor.alternative辻本, 豪三ja
dc.contributor.alternative平澤, 明ja
dc.contributor.alternative市村, 敦彦ja
dc.date.accessioned2012-03-02T05:28:45Z-
dc.date.available2012-03-02T05:28:45Z-
dc.date.issued2012-02-19ja
dc.identifier.citationIchimura A, Hirasawa A, Poulain-Godefroy O, Bonnefond A, Hara T, Yengo L, Kimura I, Leloire A, Liu N, Iida K, Choquet H, Besnard P, Lecoeur C, Vivequin S, Ayukawa K, Takeuchi M, Ozawa K, Tauber M, Maffeis C, Morandi A, Buzzetti R, Elliott P, Pouta A, Jarvelin MR, Körner A, Kiess W, Pigeyre M, Caiazzo R, Van Hul W, Van Gaal L, Horber F, Balkau B, Lévy-Marchal C, Rouskas K, Kouvatsi A, Hebebrand J, Hinney A, Scherag A, Pattou F, Meyre D, Koshimizu TA, Wolowczuk I, Tsujimoto G, Froguel P. Dysfunction of lipid sensor GPR120 leads to obesity in both mouse and human. Nature. 2012 Feb 19. doi: 10.1038/nature10798.ja
dc.identifier.issn1476-4687ja
dc.identifier.urihttp://hdl.handle.net/2433/153278-
dc.description脂肪センサーGPR120が食事性肥満の原因遺伝子であることの発見. 京都大学プレスリリース. 2012-02-20.ja
dc.description.abstractFree fatty acids provide an important energy source as nutrients, and act as signalling molecules in various cellular processes. Several G-protein-coupled receptors have been identified as free-fatty-acid receptors important in physiology as well as in several diseases. GPR120 (also known as O3FAR1) functions as a receptor for unsaturated long-chain free fatty acids and has a critical role in various physiological homeostasis mechanisms such as adipogenesis, regulation of appetite and food preference. Here we show that GPR120-deficient mice fed a high-fat diet develop obesity, glucose intolerance and fatty liver with decreased adipocyte differentiation and lipogenesis and enhanced hepatic lipogenesis. Insulin resistance in such mice is associated with reduced insulin signalling and enhanced inflammation in adipose tissue. In human, we show that GPR120 expression in adipose tissue is significantly higher in obese individuals than in lean controls. GPR120 exon sequencing in obese subjects reveals a deleterious non-synonymous mutation (p.R270H) that inhibits GPR120 signalling activity. Furthermore, the p.R270H variant increases the risk of obesity in European populations. Overall, this study demonstrates that the lipid sensor GPR120 has a key role in sensing dietary fat and, therefore, in the control of energy balance in both humans and rodents.ja
dc.format.mimetypeapplication/pdfja
dc.language.isoengja
dc.publisherNature Publishing Groupja
dc.rights©2012 Macmillan Publishers Limited. All rights reservedja
dc.rights許諾条件により本文は2012-08-19に公開.ja
dc.rightsThis is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。ja
dc.titleDysfunction of lipid sensor GPR120 leads to obesity in both mouse and human.ja
dc.identifier.urlhttp://www.nature.com/nature/journal/vaop/ncurrent/full/nature10798.htmlja
dc.type.niitypeJournal Articleja
dc.identifier.jtitleNatureja
dc.relation.doi10.1038/nature10798ja
dc.textversionauthorja
dc.startdate.bitstreamsavailable2012-08-19ja
dc.identifier.pmid22343897ja
dc.relation.urlhttp://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2011/120220_1.htmja
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