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Title: Response of ERβ and aromatase expression in the monkey hippocampal formation to ovariectomy and menopause.
Authors: Higaki, Sayuri
Takumi, Ken
Itoh, Mariko
Watanabe, Gen
Taya, Kazuyoshi
Shimizu, Keiko
Hayashi, Motoharu
Oishi, Takao  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0003-1067-3746 (unconfirmed)
Author's alias: 大石, 高生
Keywords: Estrogen receptor beta
Aging
Hippocampus
Macaque
Issue Date: Feb-2012
Publisher: Elsevier Ireland Ltd and the Japan Neuroscience Society
Journal title: Neuroscience research
Volume: 72
Issue: 2
Start page: 148
End page: 154
Abstract: Changes in the expression of estrogen-related substances in monkeys' brains at the menopausal transition, when estrogen deficit starts to occur, have not yet been examined thoroughly. In the present study, we immunohistochemically investigated the expression levels of estrogen receptor beta (ERβ) and aromatase (local estrogen synthesizing enzyme) in the hippocampal formation of premenopausal, menopausal, and ovariectomized premenopausal monkeys. In all monkeys tested, ERβ immunoreactivity was observed in interneurons located in the subiculum and the Ammon's horn, and most of these ERβ-immunoreactive neurons coexpressed a GABAergic neuron marker, parvalbumin. In the menopausal monkeys who exhibited a decline in estrogen concentration, hippocampal ERβ was highly upregulated, while aromatase expression was not markedly changed. By contrast, aromatase in the ovariectomized monkeys was significantly upregulated, while ERβ expression was not changed. In the brains of ovariectomized and menopausal monkeys, depletion of ovary-derived estrogen brought about different reactions which may be attributed to the senescence of brain aging.
Rights: © 2011 Elsevier Ireland Ltd and the Japan Neuroscience Society.
この論文は著者最終稿です。内容が印刷版と異なることがありますので、引用の際には出版社版をご確認ご利用ください。This is the Accepted Author Manuscript. Please cite only the published version.
URI: http://hdl.handle.net/2433/153279
DOI(Published Version): 10.1016/j.neures.2011.10.007
PubMed ID: 22051040
Appears in Collections:Journal Articles

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