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j.virol.2011.11.024.pdf | 1.47 MB | Adobe PDF | 見る/開く |
タイトル: | Lymph nodes harbor viral reservoirs that cause rebound of plasma viremia in SIV-infected macaques upon cessation of combined antiretroviral therapy. |
著者: | Horiike, Mariko Iwami, Shingo Kodama, Makoto Sato, Akihiko Watanabe, Yuji Yasui, Mika Ishida, Yuki Kobayashi, Takeshi Miura, Tomoyuki https://orcid.org/0000-0002-1956-2180 (unconfirmed) Igarashi, Tatsuhiko |
著者名の別形: | 五十嵐, 樹彦 |
キーワード: | SIV antiretroviral therapy HIV-1 HAART rebound of plasma viremia reservoirs animal model |
発行日: | 20-Feb-2012 |
出版者: | Elsevier B.V. |
誌名: | Virology |
巻: | 423 |
号: | 2 |
開始ページ: | 107 |
終了ページ: | 118 |
抄録: | Attempts to find a cure for HIV infection are hindered by the presence of viral reservoirs that resist highly active antiretroviral therapy. To identify the properties of these reservoirs, four SIV239-infected Rhesus macaques were treated with combined antiretroviral therapy (cART) for 1 year. While plasma viral RNA (vRNA) was effectively suppressed, a systemic analysis revealed that vRNA was distributed in the following order: lymphatic tissues>lungs and intestine>other tissues. Histochemistry yielded no cells with viral signals. To increase the chance of detection, two additional SIV-infected animals were treated and analyzed on Day 10 after the cessation of cART. These animals exhibited similar vRNA distribution patterns to the former animals, and immunohistochemistry revealed Nef-positive T lymphocytes predominantly in the follicles of mesenteric lymph nodes (MLNs). These data suggest that lymphatic tissues, including MLNs, contain major cellular reservoirs that cause rebound of plasma viremia upon cessation of therapy. |
著作権等: | © 2011 Elsevier B.V. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/153287 |
DOI(出版社版): | 10.1016/j.virol.2011.11.024 |
PubMed ID: | 22196013 |
出現コレクション: | 学術雑誌掲載論文等 |
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