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Title: Systems biology and systems chemistry: new directions for drug discovery.
Authors: Brown, J B  kyouindb  KAKEN_id
Okuno, Yasushi  kyouindb  KAKEN_id
Author's alias: 奥野, 恭史
Issue Date: 27-Jan-2012
Publisher: Elsevier Ltd.
Journal title: Chemistry & biology
Volume: 19
Issue: 1
Start page: 23
End page: 28
Abstract: Improvements in drug design have historically been centered around structure-based optimization of molecule specificity for a targeted protein, in an effort to reduce unintentional binding to other proteins and off-target effects. Although the "one-to-one" drug design strategy has been successful in impairing function of targets associated with a number of diseases, recent reports of drug promiscuity, which are a potential source of adverse reactions in patients, make a case to refine the drug design strategy such that it includes an awareness of multiple interactions from both ligand and protein perspectives. Polypharmacology and chemical biology studies are amassing interaction data at rapid rates, and the integration of such data into an interpretable model requires zooming our perspective out from the single ligand-target level to the larger network-wide level. We review some of the recent developments in systems-level research for drug design and discovery, and discuss the directions that some drug design efforts are heading toward.
Rights: © 2012 Elsevier Ltd.
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
DOI(Published Version): 10.1016/j.chembiol.2011.12.012
PubMed ID: 22284351
Appears in Collections:Journal Articles

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