このアイテムのアクセス数: 252

このアイテムのファイル:
ファイル 記述 サイズフォーマット 
s00228-011-1129-x.pdf1.81 MBAdobe PDF見る/開く
タイトル: Significance of trough monitoring for tacrolimus blood concentration and calcineurin activity in adult patients undergoing primary living-donor liver transplantation.
著者: Yano, Ikuko  KAKEN_id
Masuda, Satohiro
Egawa, Hiroto
Sugimoto, Mitsuhiro
Fukudo, Masahide
Yoshida, Yuko
Hashi, Sachiyo
Yoshizawa, Atsushi  kyouindb  KAKEN_id
Ogura, Yasuhiro
Ogawa, Kohei  KAKEN_id
Mori, Akira  KAKEN_id
Kaido, Toshimi  kyouindb  KAKEN_id
Uemoto, Shinji  kyouindb  KAKEN_id
Inui, Ken-Ichi
著者名の別形: 矢野, 育子
キーワード: LDLT
Pharmacodynamics
Pharmacokinetics
Therapeutic drug monitoring
発行日: Mar-2012
出版者: Springer-Verlag
誌名: European journal of clinical pharmacology
巻: 68
号: 3
開始ページ: 259
終了ページ: 266
抄録: [Purpose] : Tacrolimus pharmacokinetics and calcineurin activity in peripheral blood mononuclear cells (PBMCs) were investigated in adult patients undergoing primary living-donor liver transplantation (LDLT) in order to clarify the significance of monitoring the tacrolimus blood trough concentration during the early post-transplantation period. [Methods] : Fourteen patients were enrolled in this study, and time-course data following the oral administration of a conventional tacrolimus formulation twice daily were obtained at 1 and 3 weeks post-transplantation. The concentration of tacrolimus in whole blood and calcineurin activity in PBMCs were measured. [Results] : The apparent clearance of tacrolimus significantly increased at 3 weeks versus 1 week post-transplantation, although the trough concentration did not significantly differ at these time points. The concentration at each sampling time, except at 1 h post-dose, correlated well with the area under the concentration–time curve from 0 to 12 h (AUC0–12). Neither the concentration at the trough time point nor AUC0–12 was correlated with the area under the calcineurin activity–time curve from 0 to 12 h; however, calcineurin activity at the trough time point was strongly correlated with the latter (r 2 > 0.92). [Conclusions] : Based on these results, trough concentration monitoring can be considered an appropriate procedure for routine tacrolimus dosage adjustment in adult LDLT patients. Monitoring of calcineurin activity at the trough time point was also found to be potentially useful for predicting the immunological status of the patient during the tacrolimus dosing interval.
著作権等: The final publication is available at www.springerlink.com
This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
URI: http://hdl.handle.net/2433/154556
DOI(出版社版): 10.1007/s00228-011-1129-x
PubMed ID: 21969228
出現コレクション:学術雑誌掲載論文等

アイテムの詳細レコードを表示する

Export to RefWorks


出力フォーマット 


このリポジトリに保管されているアイテムはすべて著作権により保護されています。