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dc.contributor.author | Nagatomo, Fumiko | en |
dc.contributor.author | Fujino, Hidemi | en |
dc.contributor.author | Kondo, Hiroyo | en |
dc.contributor.author | Takeda, Isao | en |
dc.contributor.author | Tsuda, Kinsuke | en |
dc.contributor.author | Ishihara, Akihiko | en |
dc.contributor.alternative | 石原, 昭彦 | ja |
dc.date.accessioned | 2012-04-04T05:27:52Z | - |
dc.date.available | 2012-04-04T05:27:52Z | - |
dc.date.issued | 2012-02 | - |
dc.identifier.issn | 0271-5317 | - |
dc.identifier.uri | http://hdl.handle.net/2433/154762 | - |
dc.description.abstract | Animal models of type 2 diabetes exhibit reduced peroxisome proliferator-activated receptor-γ coactivator-1α (PGC-1α) messenger RNA (mRNA) levels, which are associated with decreased oxidative capacity, in skeletal muscles. In contrast, animal models with metabolic syndrome show normal PGC-1α mRNA levels. We hypothesized that a high-fat diet decreases PGC-1α mRNA levels in skeletal muscles of rats with metabolic syndrome, reducing muscle oxidative capacity and accelerating metabolic syndrome or inducing type 2 diabetes. We examined mRNA levels and fiber profiles in the soleus muscles of rats with metabolic syndrome (SHR/NDmcr-cp [cp/cp]; CP) fed a high-fat diet. Five-week-old CP rats were assigned to a sedentary group (CP-N) that was fed a standard diet (15.1 kJ/g, 23.6% protein, 5.3% fat, and 54.4% carbohydrates) or a sedentary group (CP-H) that was fed a high-fat diet (21.6 kJ/g, 23.6% protein, 34.9% fat, and 25.9% carbohydrates) and were housed for 10 weeks. Body weight, energy intake, and systolic blood pressure were higher in the CP-H group than in the CP-N group. Nonfasting glucose, triglyceride, total cholesterol, and leptin levels were higher in the CP-H group than in the CP-N group. There was no difference in insulin levels between the CP-N and CP-H groups. Muscle PGC-1α mRNA levels and succinate dehydrogenase activity were lower in the CP-H group than in the CP-N group. We concluded that a high-fat diet reduces PGC-1α mRNA levels and oxidative capacity in skeletal muscles and accelerates metabolic syndrome. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Elsevier Inc. | en |
dc.rights | © 2012 Elsevier Inc. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | Muscle fiber type | en |
dc.subject | Muscle oxidative enzyme activity | en |
dc.subject | Obesity | en |
dc.subject | Skeletal muscle | en |
dc.title | High-fat diet-induced reduction of peroxisome proliferator-activated receptor-γ coactivator-1α messenger RNA levels and oxidative capacity in the soleus muscle of rats with metabolic syndrome. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA11535322 | - |
dc.identifier.jtitle | Nutrition research (New York, N.Y.) | en |
dc.identifier.volume | 32 | - |
dc.identifier.issue | 2 | - |
dc.identifier.spage | 144 | - |
dc.identifier.epage | 151 | - |
dc.relation.doi | 10.1016/j.nutres.2011.12.015 | - |
dc.textversion | author | - |
dc.identifier.pmid | 22348463 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
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