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j.neurobiolaging.2011.10.033.pdf | 1.53 MB | Adobe PDF | 見る/開く |
タイトル: | Selective white matter abnormalities in a novel rat model of vascular dementia. |
著者: | Kitamura, Akihiro Fujita, Youshi Oishi, Naoya Kalaria, Raj N Washida, Kazuo Maki, Takakuni Okamoto, Yoko Hase, Yoshiki Yamada, Mahito Takahashi, Jun Ito, Hidefumi Tomimoto, Hidekazu Fukuyama, Hidenao Takahashi, Ryosuke https://orcid.org/0000-0002-1407-9640 (unconfirmed) Ihara, Masafumi |
著者名の別形: | 猪原, 匡史 |
キーワード: | Vascular dementia Chronic cerebral hypoperfusion Ameroid constrictor White matter change Rat Neurovascular coupling |
発行日: | May-2012 |
出版者: | Elsevier Inc. |
誌名: | Neurobiology of aging |
巻: | 33 |
号: | 5 |
開始ページ: | 1012.e25 |
終了ページ: | 1012.e35 |
抄録: | Rats subjected to bilateral common carotid artery (CCA) occlusion or 2-vessel occlusion (2VO) have been used as animal models of subcortical ischemic vascular dementia. However, this model possesses an inherent limitation in that cerebral blood flow (CBF) drops too sharply and substantially after ligation of CCAs. To circumvent such hypoxic-ischemic conditions, we tested implantation of the ameroid constrictor device on bilateral CCAs of male Wistar-Kyoto rats and more precisely replicated chronic cerebral hypoperfusion by gradual narrowing of the CCAs (2-vessel gradual occlusion; 2VGO). The acute cerebral blood flow reduction and resultant inflammatory responses observed in the 2VO rats were eliminated in the 2VGO rats. Thus, chronic cerebral hypoperfusion was segregated, and induced selective white matter changes with relatively preserved neurovascular coupling and substantially less metabolic and histological derangements in the gray matter including the hippocampus. This led to significant spatial working memory impairment of a magnitude similar to the 2VO rats at 28 days postoperation. The 2VGO model may more closely mimic cognitive impairment subsequent to selective white matter damage. |
著作権等: | © 2012 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/154844 |
DOI(出版社版): | 10.1016/j.neurobiolaging.2011.10.033 |
PubMed ID: | 22133276 |
出現コレクション: | 学術雑誌掲載論文等 |
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