ダウンロード数: 499
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
12_2011_161.pdf | 1.35 MB | Adobe PDF | 見る/開く |
タイトル: | Design of Biointerfaces for Regenerative Medicine |
著者: | Arima, Yusuke Kato, Koichi Teramura, Yuji Iwata, Hiroo |
著者名の別形: | 有馬, 祐介 岩田, 博夫 |
キーワード: | Amphiphilic polymer Cell adhesion Chimeric protein Islet of Langerhans Self-assembled monolayer Stem cell |
発行日: | 2012 |
出版者: | Springer-Verlag |
誌名: | Advances in Polymer Science |
巻: | 247 |
開始ページ: | 167 |
終了ページ: | 200 |
抄録: | Understanding and controlling biological responses against artificial materials is important for the development of medical devices and therapies. Self-assembled monolayers (SAMs) of alkanethiols provide well-defined surfaces that can be manipulated by varying the terminal functional groups. Thus, SAMs have been extensively used as a platform for studying how artificial materials affect biological responses. Here, we review cell adhesion behavior in response to SAMs with various surface properties and the effects that adsorbed proteins have on subsequent cell adhesion. We also describe an application for SAMs as a substrate for culturing neural stem cells (NSCs). Substrates that induced the correct orientation of immobilized growth factors, like epidermal growth factor, improved the selection of a pure NSC population during cell expansion. In addition, we review new methodologies for using amphiphilic polymers to modify the surfaces of cells and tissues. Coating the cell surface with amphiphilic polymers that can capture and immobilize bioactive substances or cells represents a promising approach for clinical applications, particularly cellular therapies. |
著作権等: | The final publication is available at www.springerlink.com この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/154891 |
DOI(出版社版): | 10.1007/12_2011_161 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。