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dc.contributor.author | Harada, Hiroshi | en |
dc.contributor.author | Inoue, Masahiro | en |
dc.contributor.author | Itasaka, Satoshi | en |
dc.contributor.author | Hirota, Kiichi | en |
dc.contributor.author | Morinibu, Akiyo | en |
dc.contributor.author | Shinomiya, Kazumi | en |
dc.contributor.author | Zeng, Lihua | en |
dc.contributor.author | Ou, Guangfei | en |
dc.contributor.author | Zhu, Yuxi | en |
dc.contributor.author | Yoshimura, Michio | en |
dc.contributor.author | McKenna, W. Gillies | en |
dc.contributor.author | Muschel, Ruth J. | en |
dc.contributor.author | Hiraoka, Masahiro | en |
dc.contributor.alternative | 原田, 浩 | ja |
dc.date.accessioned | 2012-04-18T01:35:12Z | - |
dc.date.available | 2012-04-18T01:35:12Z | - |
dc.date.issued | 2012-04-17 | - |
dc.identifier.issn | 2041-1723 | - |
dc.identifier.uri | http://hdl.handle.net/2433/155045 | - |
dc.description | 放射線治療後のがんの再発メカニズムの解明. 2012-4-18. | ja |
dc.description.abstract | Tumour recurrence frequently occurs after radiotherapy, but the characteristics, intratumoural localization and post-irradiation behaviour of radioresistant cancer cells remain largely unknown. Here we develop a sophisticated strategy to track the post-irradiation fate of the cells, which exist in perinecrotic regions at the time of radiation. Although the perinecrotic tumour cells are originally hypoxia-inducible factor 1 (HIF-1)-negative, they acquire HIF-1 activity after surviving radiation, which triggers their translocation towards tumour blood vessels. HIF-1 inhibitors suppress the translocation and decrease the incidence of post-irradiation tumour recurrence. For the first time, our data unveil the HIF-1-dependent cellular dynamics during post-irradiation tumour recurrence and provide a rational basis for targeting HIF-1 after radiation therapy. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Nature Publishing Group | en |
dc.rights | © 2012 Nature Publishing Group | en |
dc.rights | This work is licensed under a Creative Commons Attribution-NonCommercial-Share Alike 3.0 Unported License. To view a copy of this license, visit http://creativecommons.org/licenses/by-nc-sa/3.0/ | en |
dc.subject | Biological sciences | en |
dc.subject | Cancer | en |
dc.subject | Medical research | en |
dc.subject | Molecular biology | en |
dc.title | Cancer cells that survive radiation therapy acquire HIF-1 activity and translocate towards tumour blood vessels | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.jtitle | Nature Communications | en |
dc.identifier.volume | 3 | - |
dc.identifier.spage | 1 | - |
dc.identifier.epage | 10 | - |
dc.relation.doi | 10.1038/ncomms1786 | - |
dc.textversion | publisher | - |
dc.identifier.artnum | 783 | - |
dc.identifier.pmid | 22510688 | - |
dc.relation.url | http://www.kyoto-u.ac.jp/ja/news_data/h/h1/news6/2012/120418_1.htm | - |
dcterms.accessRights | open access | - |
dc.identifier.eissn | 2041-1723 | - |
出現コレクション: | 学術雑誌掲載論文等 |
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