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Title: Mechanisms of Membrane Curvature Generation in Membrane Traffic
Authors: Shin, Hye-Won  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0002-9138-9554 (unconfirmed)
Takatsu, Hiroyuki
Nakayama, Kazuhisa  kyouindb  KAKEN_id  orcid https://orcid.org/0000-0001-7701-7183 (unconfirmed)
Author's alias: 申, 惠媛
Keywords: membrane trafficking
small GTPase
BAR domain
P4-ATPase
membrane curvature
Issue Date: Mar-2012
Publisher: MDPI
Journal title: Membranes
Volume: 2
Issue: 1
Start page: 118
End page: 133
Abstract: During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins. In addition, membrane deformation entails changes in the lipid composition as well as asymmetric distribution of lipids over the two leaflets of the membrane bilayer. Given that P4-ATPases, which catalyze unidirectional flipping of lipid molecules from the exoplasmic to the cytoplasmic leaflets of the bilayer, are crucial for the trafficking of proteins in the secretory and endocytic pathways, changes in the lipid composition are involved in the vesicular trafficking process. Membrane remodeling is under complex regulation that involves the composition and distribution of lipids as well as assembly of proteins.
Rights: © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/).
URI: http://hdl.handle.net/2433/155094
DOI(Published Version): 10.3390/membranes2010118
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