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タイトル: | Mechanisms of Membrane Curvature Generation in Membrane Traffic |
著者: | Shin, Hye-Won https://orcid.org/0000-0002-9138-9554 (unconfirmed) Takatsu, Hiroyuki Nakayama, Kazuhisa https://orcid.org/0000-0001-7701-7183 (unconfirmed) |
著者名の別形: | 申, 惠媛 |
キーワード: | membrane trafficking small GTPase BAR domain P4-ATPase membrane curvature |
発行日: | Mar-2012 |
出版者: | MDPI AG |
誌名: | Membranes |
巻: | 2 |
号: | 1 |
開始ページ: | 118 |
終了ページ: | 133 |
抄録: | During the vesicular trafficking process, cellular membranes undergo dynamic morphological changes, in particular at the vesicle generation and fusion steps. Changes in membrane shape are regulated by small GTPases, coat proteins and other accessory proteins, such as BAR domain-containing proteins. In addition, membrane deformation entails changes in the lipid composition as well as asymmetric distribution of lipids over the two leaflets of the membrane bilayer. Given that P4-ATPases, which catalyze unidirectional flipping of lipid molecules from the exoplasmic to the cytoplasmic leaflets of the bilayer, are crucial for the trafficking of proteins in the secretory and endocytic pathways, changes in the lipid composition are involved in the vesicular trafficking process. Membrane remodeling is under complex regulation that involves the composition and distribution of lipids as well as assembly of proteins. |
著作権等: | © 2012 by the authors; licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution license (http://creativecommons.org/licenses/by/3.0/). |
URI: | http://hdl.handle.net/2433/155094 |
DOI(出版社版): | 10.3390/membranes2010118 |
PubMed ID: | 24957965 |
出現コレクション: | 学術雑誌掲載論文等 |
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