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タイトル: | An Overview of a Wide Range of Functions of ZnT and Zip Zinc Transporters in the Secretory Pathway |
著者: | KAMBE, Taiho https://orcid.org/0000-0001-9757-063X (unconfirmed) |
著者名の別形: | 神戸, 大朋 |
キーワード: | zinc Slc30a/ZnT Slc39a/Zip secretory pathway zinc-requiring enzymes |
発行日: | Jun-2011 |
出版者: | Japan Society for Bioscience, Biotechnology, and Agrochemistry |
誌名: | Bioscience, Biotechnology, and Biochemistry |
巻: | 75 |
号: | 6 |
開始ページ: | 1036 |
終了ページ: | 1043 |
抄録: | Zinc plays essential roles in the early secretory pathway for a number of secretory, membrane-bound, and endosome/lysosome-resident enzymes. It enables the enzymes to fold properly and become functional, by binding as a structural or catalytic component. Moreover, zinc secreted from the secretory vesicles/granules into the extracellular space has a pivotal role as a signaling molecule for various physiological functions. Zinc transporters of the Slc30a/ZnT and Slc39a/Zip families play crucial roles in these functions, mediating zinc influx to and efflux from the lumen of the secretory pathway, constitutively or in a cell-specific manner. This paper reviews current knowledge of the ways these two zinc transporters perform these tasks by manipulating zinc homeostasis in the secretory pathway. Recent questions concerning zinc released into the cytoplasm from the secretory pathway, which then functions as an intracellular signaling molecule, are also briefly reviewed, emphasizing zinc transporter functions. |
著作権等: | (c) 2011 by Japan Society for Bioscience, Biotechnology, and Agrochemistry |
URI: | http://hdl.handle.net/2433/156507 |
DOI(出版社版): | 10.1271/bbb.110056 |
PubMed ID: | 21670538 |
関連リンク: | https://www.jstage.jst.go.jp/article/bbb/75/6/75_110056/_article |
出現コレクション: | 学術雑誌掲載論文等 |
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