ダウンロード数: 223
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
jjco_hyr045.pdf | 281.11 kB | Adobe PDF | 見る/開く |
完全メタデータレコード
DCフィールド | 値 | 言語 |
---|---|---|
dc.contributor.author | Zaima, C | en |
dc.contributor.author | Kanai, M | en |
dc.contributor.author | Ishikawa, S | en |
dc.contributor.author | Kawaguchi, Y | en |
dc.contributor.author | Masui, T | en |
dc.contributor.author | Mori, Y | en |
dc.contributor.author | Nishimura, T | en |
dc.contributor.author | Matsumoto, S | en |
dc.contributor.author | Yanagihara, K | en |
dc.contributor.author | Chiba, T | en |
dc.contributor.author | Mimori, T | en |
dc.contributor.alternative | 金井, 雅史 | ja |
dc.date.accessioned | 2012-06-25T01:38:06Z | - |
dc.date.available | 2012-06-25T01:38:06Z | - |
dc.date.issued | 2011-06 | - |
dc.identifier.issn | 0368-2811 | - |
dc.identifier.uri | http://hdl.handle.net/2433/156782 | - |
dc.description.abstract | The safety of chemotherapy for patients with systemic sclerosis is unclear, and there are few published reports documenting the side effects of chemotherapy in patients with this condition. Here, we report the case of a patient with systemic sclerosis who developed severe digital ischemia during combination gemcitabine/S-1 chemotherapy for pancreatic cancer. In spite of aggressive treatment, the digital ischemia progressively worsened and gangrenous changes developed in multiple fingers and toes. In this patient, the systemic sclerosis had been well controlled, with no digital ischemic symptoms for the previous 6 years, so this progressive clinical course in spite of aggressive treatment strongly suggests that the chemotherapy triggered or aggravated the digital necrosis. To the best of our knowledge, this is only the third reported case of a patient with systemic sclerosis developing digital necrosis after gemcitabine-based chemotherapy. The incidence of digital necrosis during chemotherapy in patients with systemic sclerosis is unknown, and the mechanism by which it occurs is unclear, but the three reports published to date, including the present case, suggest that physicians should be very cautious about administering gemcitabine-based chemotherapy to patients with systemic sclerosis. Any resulting digital ischemia might be refractory to treatment and worsen progressively, even if chemotherapy is withdrawn in the early stages of digital ischemia. | en |
dc.format.mimetype | application/pdf | - |
dc.language.iso | eng | - |
dc.publisher | Oxford University Press | en |
dc.rights | © The Author (2011). Published by Oxford University Press. | en |
dc.rights | This is not the published version. Please cite only the published version. | en |
dc.rights | この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 | ja |
dc.subject | gemcitabine | en |
dc.subject | necrosis | en |
dc.subject | S-1 | en |
dc.subject | systemic scleroderma | en |
dc.subject | toxicity | en |
dc.subject.mesh | Aged | en |
dc.subject.mesh | Antimetabolites, Antineoplastic/administration & dosage | en |
dc.subject.mesh | Antimetabolites, Antineoplastic/adverse effects | en |
dc.subject.mesh | Antineoplastic Combined Chemotherapy Protocols/therapeutic use | en |
dc.subject.mesh | Deoxycytidine/administration & dosage | en |
dc.subject.mesh | Deoxycytidine/adverse effects | en |
dc.subject.mesh | Deoxycytidine/analogs & derivatives | en |
dc.subject.mesh | Disease Progression | en |
dc.subject.mesh | Drug Administration Schedule | en |
dc.subject.mesh | Drug Combinations | en |
dc.subject.mesh | Fatal Outcome | en |
dc.subject.mesh | Fingers/pathology | en |
dc.subject.mesh | Gangrene/chemically induced | en |
dc.subject.mesh | Humans | en |
dc.subject.mesh | Ischemia/chemically induced | en |
dc.subject.mesh | Ischemia/drug therapy | en |
dc.subject.mesh | Ischemia/etiology | en |
dc.subject.mesh | Ischemia/therapy | en |
dc.subject.mesh | Male | en |
dc.subject.mesh | Necrosis/chemically induced | en |
dc.subject.mesh | Oxonic Acid/administration & dosage | en |
dc.subject.mesh | Oxonic Acid/adverse effects | en |
dc.subject.mesh | Pancreatic Neoplasms/complications | en |
dc.subject.mesh | Pancreatic Neoplasms/drug therapy | en |
dc.subject.mesh | Pancreatic Neoplasms/pathology | en |
dc.subject.mesh | Peritoneal Neoplasms/drug therapy | en |
dc.subject.mesh | Peritoneal Neoplasms/secondary | en |
dc.subject.mesh | Raynaud Disease/chemically induced | en |
dc.subject.mesh | Scleroderma, Systemic/complications | en |
dc.subject.mesh | Tegafur/administration & dosage | en |
dc.subject.mesh | Tegafur/adverse effects | en |
dc.subject.mesh | Toes/pathology | en |
dc.title | A case of progressive digital ischemia after early withdrawal of gemcitabine and S-1 in a patient with systemic sclerosis. | en |
dc.type | journal article | - |
dc.type.niitype | Journal Article | - |
dc.identifier.ncid | AA00690866 | - |
dc.identifier.jtitle | Japanese journal of clinical oncology | en |
dc.identifier.volume | 41 | - |
dc.identifier.issue | 6 | - |
dc.identifier.spage | 803 | - |
dc.identifier.epage | 806 | - |
dc.relation.doi | 10.1093/jjco/hyr045 | - |
dc.textversion | author | - |
dc.identifier.pmid | 21478179 | - |
dcterms.accessRights | open access | - |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。