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タイトル: Bone regeneration by lactoferrin released from a gelatin hydrogel.
著者: Takaoka, Ryohei
Hikasa, Yoshiaki
Hayashi, Kentaro
Tabata, Yasuhiko  KAKEN_id
著者名の別形: 田畑, 泰彦
キーワード: LACTOFERRIN
BONE REGENERATION
SUSTAINED RELEASE
発行日: 2011
出版者: Taylor & Francis
誌名: Journal of biomaterials science. Polymer edition
巻: 22
号: 12
開始ページ: 1581
終了ページ: 1589
抄録: The objective of this study is to evaluate the potential of lactoferrin (LF), an iron-binding glycoprotein, to induce bone regeneration. A biodegradable gelatin hydrogel was prepared to allow LF release in vivo in a sustained fashion. When subcutaneously implanted into the back of mice, the gelatin hydrogel incorporating LF showed a longer LF retention period at the site of implantation than that of LF solution injection. An in vitro culture experiment with 3T3E1 cells (mouse-derived osteoblasts) revealed that the cells were proliferated to a significantly greater extent by the repeated addition of LF compared with a single addition of LF at the same dose. Following the implantation of gelatin hydrogels incorporating LF into a skull bone defect of rats, a significantly stronger bone regeneration at the defect was observed than in LF-free- or low-LF-treated rats. It is concluded that the sustained release from the gelatin hydrogels enables LF to enhance the in vivo activity of bone regeneration.
著作権等: © 2011 Taylor & Francis
この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。
This is not the published version. Please cite only the published version.
URI: http://hdl.handle.net/2433/156795
DOI(出版社版): 10.1163/092050610X517095
PubMed ID: 20663279
出現コレクション:学術雑誌掲載論文等

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