ダウンロード数: 581
このアイテムのファイル:
ファイル | 記述 | サイズ | フォーマット | |
---|---|---|---|---|
092050610X517095.pdf | 418.94 kB | Adobe PDF | 見る/開く |
タイトル: | Bone regeneration by lactoferrin released from a gelatin hydrogel. |
著者: | Takaoka, Ryohei Hikasa, Yoshiaki Hayashi, Kentaro Tabata, Yasuhiko |
著者名の別形: | 田畑, 泰彦 |
キーワード: | LACTOFERRIN BONE REGENERATION SUSTAINED RELEASE |
発行日: | 2011 |
出版者: | Taylor & Francis |
誌名: | Journal of biomaterials science. Polymer edition |
巻: | 22 |
号: | 12 |
開始ページ: | 1581 |
終了ページ: | 1589 |
抄録: | The objective of this study is to evaluate the potential of lactoferrin (LF), an iron-binding glycoprotein, to induce bone regeneration. A biodegradable gelatin hydrogel was prepared to allow LF release in vivo in a sustained fashion. When subcutaneously implanted into the back of mice, the gelatin hydrogel incorporating LF showed a longer LF retention period at the site of implantation than that of LF solution injection. An in vitro culture experiment with 3T3E1 cells (mouse-derived osteoblasts) revealed that the cells were proliferated to a significantly greater extent by the repeated addition of LF compared with a single addition of LF at the same dose. Following the implantation of gelatin hydrogels incorporating LF into a skull bone defect of rats, a significantly stronger bone regeneration at the defect was observed than in LF-free- or low-LF-treated rats. It is concluded that the sustained release from the gelatin hydrogels enables LF to enhance the in vivo activity of bone regeneration. |
著作権等: | © 2011 Taylor & Francis この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 This is not the published version. Please cite only the published version. |
URI: | http://hdl.handle.net/2433/156795 |
DOI(出版社版): | 10.1163/092050610X517095 |
PubMed ID: | 20663279 |
出現コレクション: | 学術雑誌掲載論文等 |
このリポジトリに保管されているアイテムはすべて著作権により保護されています。