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タイトル: | Tissue damage in the canine normal esophagus by photoactivation with talaporfin sodium (laserphyrin): a preclinical study. |
著者: | Horimatsu, Takahiro https://orcid.org/0000-0002-4188-9059 (unconfirmed) Muto, Manabu https://orcid.org/0000-0002-3127-8203 (unconfirmed) Yoda, Yusuke Yano, Tomonori Ezoe, Yasumasa Miyamoto, Shinichi Chiba, Tsutomu |
著者名の別形: | 堀松, 高博 |
発行日: | Jun-2012 |
出版者: | Public Library of Science |
誌名: | PloS one |
巻: | 7 |
号: | 6 |
論文番号: | e38308 |
抄録: | [Background] Treatment failure at the primary site after chemoradiotherapy is a major problem in achieving a complete response. Photodynamic therapy (PDT) with porfimer sodium (Photofrin®) has some problems such as the requirement for shielding from light for several weeks and a high incidence of skin phototoxicity. PDT with talaporfin sodium (Laserphyrin) is less toxic and is expected to have a better effect compared with Photofrin PDT. However, Laserphyrin PDT is not approved for use in the esophagus. In this preclinical study, we investigated tissue damage of the canine normal esophagus caused by photoactivation with Laserphyrin. [Methodology/Principal Findings] Diode laser irradiation was performed at 60 min after administration. An area 5 cm oral to the esophagogastric junction was irradiated at 25 J/cm2, 50 J/cm2, and 100 J/cm2 using a three-step escalation. The irradiated areas were evaluated endoscopically on postirradiation days 1 and 7, and were subjected to histological examination after autopsy. The areas injured by photoactivation were 52 mm2, 498 mm2, and 831 mm2 after irradiation at 25 J/cm2, 50 J/cm2, and 100 J/cm2, respectively. Tissue injury was observed in the muscle layer or even deeper at any irradiation level and became more severe as the irradiation dose increased. At 100 J/cm2 both inflammatory changes and necrosis were seen histologically in extra-adventitial tissue. [Conclusions/Significance]To minimize injury of the normal esophagus by photoactivation with Laserphyrin, diode laser irradiation at 25 J/cm2 appears to be safe. For human application, it would be desirable to investigate the optimal laser dose starting from this level. |
著作権等: | © 2012 Horimatsu et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | http://hdl.handle.net/2433/157362 |
DOI(出版社版): | 10.1371/journal.pone.0038308 |
PubMed ID: | 22719875 |
出現コレクション: | 学術雑誌掲載論文等 |
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