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Title: The effect of β-2 adrenoreceptor agonist inhalation on lungs donated after cardiac death in a canine lung transplantation model.
Authors: Sakamoto, Jin
Chen, Fengshi
Nakajima, Daisuke
Yamada, Tetsu
Ohsumi, Akihiro
Zhao, Xiangdong  kyouindb  KAKEN_id  orcid (unconfirmed)
Sakai, Hiroaki
Bando, Toru
Date, Hiroshi
Author's alias: 阪本, 仁
伊達, 洋至
Keywords: β-2 adrenoreceptor agonist
canine model
donation after cardiac death
lung transplantation
Issue Date: Jul-2012
Publisher: Elsevier Inc.
Journal title: The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation
Volume: 31
Issue: 7
Start page: 773
End page: 779
Abstract: [Background]It is a matter of great importance in a donation after cardiac death to attenuate ischemia–reperfusion injury (IRI) related to the inevitable warm ischemic time. [Methods]Donor dogs were rendered cardiac-dead and left at room temperature. The dogs were allocated into 2 groups: the β-2 group (n = 5) received an aerosolized β-2 adrenoreceptor agonist (procaterol, 350 μg) and ventilation with 100% oxygen for 60 minutes starting at 240 minutes after cardiac arrest, and the control group (n = 6) received an aerosolized control solvent with the ventilation. Lungs were recovered 300 minutes after cardiac arrest. Recipient dogs underwent left single-lung transplantation to evaluate the functions of the left transplanted lung for 240 minutes after the reperfusion. [Results]Oxygenation and dynamic compliance were significantly higher in the β-2 group than in the control group. The β-2 group revealed significantly higher levels of cyclic adenosine monophosphate and high-energy phosphates in the donor lung after the inhalation than before it. Histologic findings revealed that the β-2 group had less edema and fewer inflammatory cells. [Conclusion]Our results suggest that β-2 adrenoreceptor agonist inhalation during the pre-procurement period may ameliorate IRI.
Rights: © 2012 International Society for Heart and Lung Transplantation. Published by Elsevier Inc.
This is not the published version. Please cite only the published version.
DOI(Published Version): 10.1016/j.healun.2012.03.012
PubMed ID: 22534458
Appears in Collections:Journal Articles

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