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タイトル: | Photoreceptor damage and foveal sensitivity in surgically closed macular holes: an adaptive optics scanning laser ophthalmoscopy study. |
著者: | Ooto, Sotaro Hangai, Masanori Takayama, Kohei Ueda-Arakawa, Naoko Hanebuchi, Masaaki Yoshimura, Nagahisa |
著者名の別形: | 大音, 壮太郎 |
発行日: | Jul-2012 |
出版者: | Elsevier Inc. |
誌名: | American journal of ophthalmology |
巻: | 154 |
号: | 1 |
開始ページ: | 174 |
終了ページ: | 186.e2 |
抄録: | [Purpose]To assess photoreceptor structure using adaptive optics scanning laser ophthalmoscopy (AO SLO) and spectral-domain optical coherence tomography (SD OCT) and to evaluate the relationship between structural abnormalities and foveal sensitivity in eyes with surgically closed macular hole (MH). [Design]Prospective, interventional case series. [Methods] Twenty-one eyes of 19 patients with idiopathic MH underwent a full ophthalmologic examination, including SD OCT at baseline. Imaging with SD OCT, an original prototype AO SLO system, and microperimetry were performed at 6 months after surgery. [Results]All patients underwent anatomically successful MH closure. On AO SLO, dark areas (0.004 to 0.754 mm^2) were seen in all eyes after MH repair. Lower cone density correlated with poorer postoperative visual acuity and lower mean foveal sensitivity (both P < .001). Larger dark areas on AO SLO correlated with poorer postoperative visual acuity (P = .003) and lower mean foveal sensitivity (P = .006). Cone density was significantly lower and dark areas were significantly larger in eyes that had defects of the outer segments in the fluid cuff before surgery (P = .018 and P = .001, respectively) and moderately reflective foveal lesions after surgery (P < .001 and P < .001, respectively). Larger dark areas correlated with longer symptom duration before surgery (P < .001). [Conclusions]Structural damage to the photoreceptor layer correlated with greater decreases in visual function in eyes with surgically closed MH. AO SLO imaging is a useful and quantitative tool for detecting photoreceptor abnormalities and their association with visual acuity and retinal sensitivity in eyes with closed MH. |
著作権等: | © 2012 Elsevier Inc. This is not the published version. Please cite only the published version. この論文は出版社版でありません。引用の際には出版社版をご確認ご利用ください。 |
URI: | http://hdl.handle.net/2433/158647 |
DOI(出版社版): | 10.1016/j.ajo.2012.01.031 |
PubMed ID: | 22534108 |
出現コレクション: | 学術雑誌掲載論文等 |
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